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AB235677

Recombinant Human CDR2 protein (His tag)

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Recombinant Human CDR2 protein (His tag) is a Human Full Length protein, in the 1 to 454 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

PCD17, CDR2, Cerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen

3 Images
Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235677 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.

Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235677 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.

SDS-PAGE - Recombinant Human CDR2 protein (His tag) (AB235677)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CDR2 protein (His tag) (AB235677)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235677.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q01850

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MLAENLVEEFEMKEDEPWYDHQDLQQDLQLAAELGKTLLDRNTELEDSVQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVADSKASQQKILSLTETIECLQTNIDHLQSQVEELKSSGQGRRSPGKCDQEKPAPSFACLKELYDLRQHFVYDHVFAEKITSLQGQPSPDEEENEHLKKTVTMLQAQLSLERQKRVTMEEEYGLVLKENSELEQQLGATGAYRARALELEAEVAEMRQMLQSEHPFVNGVEKLVPDSLYVPFKEPSQSLLEEMFLTVPESHRKPLKRSSSETILSSLAGSDIVKGHEETCIRRAKAVKQRGISLLHEVDTQYSALKVKYEELLKKCQEEQDSLSHKAVQTSRAAAKDLTGVNAQSEPVASGWELASVNPEPVSSPTTPPEYKALFKEIFSCIKKTKQEIDEQRTKYRSLSSHS","proteinLength":"Full Length","predictedMolecularWeight":"55.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":454,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q01850","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDR2 also known as Cerebellar Degeneration-Related Protein 2 weighs approximately 52 kDa. It is primarily located in neuronal tissues particularly in the cerebellum. The protein is part of a family of proteins that share similarities including CDR2L which is also found in neuronal tissues. CDR2 plays a mechanical role in regulating neuron function and growth. While it has less common names this protein is consistently referred to in studies involving paraneoplastic neurological disorders.
Biological function summary

CDR2 regulates neuronal signaling and motor control. It interacts with proteins involved in cell cycle control and may form part of a protein complex affecting protein synthesis. Recent research suggests that CDR2 operates in regulating neuronal activity and response to cellular stress. The protein’s expression patterns indicate its significance in maintaining proper cerebellar function and coordination.

Pathways

CDR2 aligns with signaling pathways linked to cerebellar function and neurodegeneration. It is implicated in the mTOR signaling pathway which is important for cell growth and survival alongside proteins like mTOR and RICTOR. The protein is also associated with the beta-catenin signaling pathway suggesting its involvement in processes like cytoskeletal organization and neural cell adhesion.

CDR2 is connected to paraneoplastic cerebellar degeneration and certain types of cancers such as ovarian and breast cancer. These diseases link to the immune response against tumors that mistakenly target neuronal tissue. The protein Yo antibodies are associated with this condition showing a strong connection to CDR2. Their presence in patients indicates an autoimmune aspect where the target’s involvement leads to cerebellar damage and subsequent motor dysfunction.

Specifications

Form

Liquid

General info

Sequence similarities

Belongs to the CDR2 family.

Product protocols

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