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AB116840

Recombinant Human CDS1 protein (GST tag N-Terminus)

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Recombinant Human CDS1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1 to 98 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

CDS, CDS1, Phosphatidate cytidylyltransferase 1, CDP-DAG synthase 1, CDP-DG synthase 1, CDP-diacylglycerol synthase 1, CDP-diglyceride pyrophosphorylase 1, CDP-diglyceride synthase 1, CTP:phosphatidate cytidylyltransferase 1, CDS 1

1 Images
SDS-PAGE - Recombinant Human CDS1 protein (GST tag N-Terminus) (AB116840)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CDS1 protein (GST tag N-Terminus) (AB116840)

12.5% SDS-PAGE Stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

Q92903

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB278496

Anti-CDS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDS1 antibody (AB278496)

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  • 0
Primary Antibodies

AB234973

Anti-CDS2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDS2 antibody (AB234973)

  • 5
  • 1
Primary Antibodies

AB246925

Anti-DPH4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPH4 antibody (AB246925)

  • 0
  • 0
Proteins & Peptides

AB276602

Recombinant Human GBP2 protein (His tag)

SDS-PAGE - Recombinant Human GBP2 protein (His tag) (AB276602)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
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Sequence info

[{"sequence":"MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDIDDRYGDLDSRTDSDIPEIPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMIS","proteinLength":"Fragment","predictedMolecularWeight":"36.41 kDa","actualMolecularWeight":null,"aminoAcidEnd":98,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q92903","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDS1 also known as CDP-diacylglycerol synthase 1 plays an important mechanical role in lipid metabolism by converting phosphatidic acid into CDP-diacylglycerol. This enzyme has a molecular mass of approximately 52 kDa and is expressed in a wide range of tissues throughout the body with notable expression in the brain heart and lungs. CDP-diacylglycerol synthase 1 participates in phospholipid biosynthesis which is essential for maintaining cell membrane integrity and function.
Biological function summary

CDP-diacylglycerol synthase 1 contributes to the regulation of phospholipid synthesis influencing the production of important signaling molecules. It functions not by forming complex with other proteins but through its enzymatic activity that provides substrates for the synthesis of phosphatidylinositol and phosphatidylglycerol. These phospholipids are fundamental components of cell membranes and play roles in signaling pathways that control cellular activities.

Pathways

CDP-diacylglycerol synthase 1 is integral to the phosphatidylinositol signaling pathway and the glycerophospholipid metabolism pathway. These pathways are critical for many cellular processes including signal transduction and membrane trafficking. Within these pathways CDS1 works in conjunction with enzymes like phospholipase C which hydrolyzes phosphatidylinositol affecting intracellular second messengers. Its activity connects with other lipid metabolizing proteins to ensure proper cell function and survival.

Researchers have linked defects in CDP-diacylglycerol synthase 1 to certain developmental and metabolic diseases notably Lowe syndrome and skeletal disorders. Its dysfunction may disrupt normal phospholipid metabolism impacting cellular signaling and structural integrity. This enzyme's alteration can affect related proteins such as enzymes responsible for phosphatidylinositol levels contributing to disease pathogenesis and necessitating targeted interventions.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed : 25375833, PubMed : 9407135). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed : 25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed : 26946540, PubMed : 31548309). Positively regulates the differentiation and development of adipocytes (By similarity).

Sequence similarities

Belongs to the CDS family.

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Product protocols

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Target data

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed : 25375833, PubMed : 9407135). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed : 25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed : 26946540, PubMed : 31548309). Positively regulates the differentiation and development of adipocytes (By similarity).
See full target information CDS1
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Product promise

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