Recombinant Human CDY1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDY1 also known as CDY1A or CDY-S is a chromodomain protein involved in transcription regulation. It weighs approximately 64 kDa and expresses mainly in testicular tissue particularly in pachytene spermatocytes and round spermatids. This protein includes both a chromodomain which binds to methylated histones and a histone acetyltransferase (HAT) domain playing a dual role in chromatin remodeling and gene expression regulation.

Biological function summary

This protein functions in the context of chromatin modification influencing gene repression and activation during spermatogenesis. CDY1 is part of chromatin remodeling complexes playing an important role in enabling or restricting the access of transcription machinery to DNA. This involvement in chromatin structure regulation is important for ensuring proper expression of genes that guide the development of male germ cells.

Pathways

CDY1 integrates into gene expression pathways related to chromatin remodeling and histone modification. It interacts with pathways that involve histone acetylation an essential process for gene activation. A notable link exists between CDY1 and the SIRT family of proteins especially SIRT1 highlighting its role in histone modification pathways that maintain genomic stability and regulate transcription during spermatogenesis.

CDY1 has relevance to certain fertility-related conditions. Abnormalities in CDY1 expression or function can lead to male infertility attributed to disrupted chromatin modification in germ cells. Furthermore CDY1 connects to DAZ proteins commonly associated with azoospermia a condition characterized by an absence of sperm in semen. Understanding CDY1’s function offers insights into male reproductive health and potential therapeutic targets for infertility.