Recombinant Human CEACAM3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CEACAM3 also known as CD66d is a membrane protein involved in cell adhesion and immune response. It weighs approximately 29 kDa and belongs to the carcinoembryonic antigen (CEA) family. CEACAM3 primarily expresses on granulocytes especially neutrophils. It plays a role in cellular interactions contributing to the body's defense against certain pathogens.

Biological function summary

CEACAM3 facilitates immune surveillance by enabling neutrophils to recognize and engulf bacteria through opsonin-independent phagocytosis. It interacts with the actin cytoskeleton dynamics although it does not form a larger protein complex. CEACAM3 binds to specific bacterial adhesins helping initiate a rapid immune response which is essential in eliminating pathogens at sites of infection.

Pathways

CEACAM3 is involved in the regulation of phagocytosis and inflammation. It activates a signaling cascade that includes proteins such as Src-family kinases and small GTPases like Rac and Cdc42 which are important for actin reorganization and engulfment of bacteria. These pathways support cellular processes essential for neutrophil-mediated clearance of infectious agents enhancing the body's ability to control bacterial infections.

Research implicates CEACAM3 in certain bacterial infections and inflammatory conditions. Dysregulation or functional impairment can lead to chronic inflammation or excessive tissue damage. CEACAM1 a related protein can modulate immune responses alongside CEACAM3 suggesting potential overlaps in their functions and impacts in these disease contexts. Understanding CEACAM3's role can help in developing therapies that target these pathways to treat bacterial infections and manage inflammation.