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AB196137

Recombinant Human CECR2 protein

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Recombinant Human CECR2 protein is a Human Fragment protein, in the 430 to 543 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

KIAA1740, CECR2, Chromatin remodeling regulator CECR2, Cat eye syndrome critical region protein 2

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SDS-PAGE - Recombinant Human CECR2 protein (AB196137)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CECR2 protein (AB196137)

4-20% SDS-PAGE analysis of 3 μg ab196137 with Coomassie staining.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BXF3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFPGED","proteinLength":"Fragment","predictedMolecularWeight":"40.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":543,"aminoAcidStart":430,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BXF3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CECR2 protein also known as Cat Eye Syndrome Chromosome Region Candidate 2 plays an important role in chromatin remodeling. It has a molecular mass of approximately 150 kDa. This protein functions as part of the CECR2-containing complex (CERF) which takes part in the regulation of nucleosome catalysis. CECR2 expresses in various tissues with notable expression in the testis brain and fetal tissue.
Biological function summary

The CECR2 protein engages in modulating transcriptional activity influencing the accessibility of DNA for transcription machinery. It acts as a component of the CERF complex integrating with multiple other proteins to facilitate these transcriptional adjustments. This action directly affects gene expression patterns critical for developmental processes particularly in neurogenesis and spermatogenesis.

Pathways

CECR2 interacts in the chromatin remodeling pathways essential for DNA replication and repair. The protein associates with SWI/SNF-like chromatin-remodeling complexes. These complexes enhance the efficient binding of transcriptional factors such as those of the BRG1/BRM-associated factor (BAF) complex. This interaction supports regulatory processes in embryonic development and cellular differentiation.

CECR2 mutations or dysregulation have strong links to neural tube defects and Cat Eye Syndrome. Neural tube defects result from improper closure of the neural tube during early embryonic development where CECR2 plays a regulatory role. The protein also relates to conditions involving altered chromatin structure. CECR2's relationship with other proteins involved in neural tube closure disorders like SHH (Sonic Hedgehog) highlights its relevance in these pathologies.
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Specifications

Form

Liquid

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General info

Function

Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed : 15640247, PubMed : 22464331, PubMed : 26365797, PubMed : 28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed : 28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed : 28801535). Plays a role in various processes during development : required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones : binds histones that are acetylated and/or butyrylated (PubMed : 22464331, PubMed : 26365797). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed : 11827465).

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Product protocols

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Target data

Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed : 15640247, PubMed : 22464331, PubMed : 26365797, PubMed : 28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed : 28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed : 28801535). Plays a role in various processes during development : required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones : binds histones that are acetylated and/or butyrylated (PubMed : 22464331, PubMed : 26365797). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed : 11827465).
See full target information CECR2
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Associated Products

Select an associated product type
Alternative Product
Proteins & Peptides

AB196136

Recombinant human CECR2 protein (Active)

proteins-peptides

recombinant-human-cecr2-protein-active-ab196136

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