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AB161644

Recombinant Human Cela3b protein (GST tag N-Terminus)

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Recombinant Human Cela3b protein (GST tag N-Terminus) is a Human Full Length protein, in the 19 to 270 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

ELA3B, CELA3B, Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E

1 Images
SDS-PAGE - Recombinant Human Cela3b protein (GST tag N-Terminus) (AB161644)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Cela3b protein (GST tag N-Terminus) (AB161644)

ab161644 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P08861

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human VISTA protein (GST tag N-Terminus) (AB163782)

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Primary Antibodies

AB21590

Anti-Elastase antibody

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Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISSSWTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":270,"aminoAcidStart":19,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P08861","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CELA3B protein also known as elastase 3B has a significant role in the digestive system. It is a serine protease with a molecular mass of approximately 28 kDa. CELA3B is expressed mainly in the pancreas and is secreted into the small intestine. Its primary mechanical function involves breaking down proteins into peptides facilitating digestion in the intestinal lumen.
Biological function summary

The process of protein digestion relies heavily on the proteolytic activity of CELA3B. The enzyme functions as a monomer and does not form a complex. Its action contributes to the efficient processing of dietary proteins making them available for further breakdown by other proteases like trypsin and chymotrypsin. CELA3B's role in protein digestion is essential for nutrient absorption and overall digestive health.

Pathways

Protein digestion pathways prominently feature the action of CELA3B. It closely interacts with trypsin and chymotrypsin activating these enzymes through initial protein cleavage. This enzyme cascade results in a coordinated protein breakdown. Moreover CELA3B is an integral part of the digestive enzyme pathway which ensures the sequential activation and function of proteolytic enzymes necessary for effective metabolism of dietary proteins.

Impaired CELA3B activity or expression links with pancreatic diseases such as chronic pancreatitis and exocrine pancreatic insufficiency. These conditions often exhibit reduced levels of CELA3B leading to digestive problems and nutrient malabsorption. The enzyme's dysregulation can also relate to cystic fibrosis where the thickening of digestive secretions affects the activity of pancreatic enzymes including CELA3B.
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Specifications

Form

Liquid

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General info

Function

Efficient protease with alanine specificity but only little elastolytic activity.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

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Product protocols

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Target data

Efficient protease with alanine specificity but only little elastolytic activity.
See full target information CELA3B
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Product promise

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