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AB174396

Recombinant Human CENPP protein (denatured) (His tag N-Terminus)

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Recombinant Human CENPP protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 288 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Centromere protein P, CENP-P, CENPP

1 Images
SDS-PAGE - Recombinant Human CENPP protein (denatured) (His tag N-Terminus) (AB174396)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CENPP protein (denatured) (His tag N-Terminus) (AB174396)

15% SDS-PAGE analysis of ab174396 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6IPU0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQLGHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEFQILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYRKRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLTKVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN","proteinLength":"Full Length","predictedMolecularWeight":"35.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":288,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q6IPU0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CENPP also known as Centromere Protein P is a component of the centromere complex particularly the CENP-H/I/K complex which plays a direct role in chromosome segregation during cell division. CENPP has an approximate molecular weight of 43 kDa. Its expression is predominantly in dividing cells especially in tissues with high mitotic activity such as bone marrow and lymphoid tissues. The protein ensures the proper attachment of centromeric regions to the spindle apparatus which is critical for accurate chromosomal movement and segregation.
Biological function summary

CENPP functions within the larger assembly of proteins that make up the kinetochore which is part of the outer centromere surface. This protein is essential for assembling the CCAN (constitutive centromere-associated network) complex an integral component in establishing kinetochore-microtubule interactions. Through this association CENPP participates in stabilizing the positioning of chromosomes on the spindle fibers ensuring equal distribution of chromatids to daughter cells.

Pathways

CENPP holds a function within centromere assembly and mitotic progression pathways. It interacts with other centromere-associated proteins like CENPA and CENPB assisting the recruitment of these proteins to centromeric regions. The accurate functioning of these pathways helps maintain genomic stability by preventing aneuploidy a condition where cells possess abnormal chromosomal numbers.

Errors in CENPP function can contribute to chromosomal instabilities which are hallmarks of various cancers including colorectal cancer and leukemia. The misregulation of CENPP may lead to improper kinetochore-microtubule attachments resulting in aneuploidy. The protein’s interaction with CENPT is important as both proteins can impact cell cycle checkpoints and their dysregulation is linked to tumorigenesis.
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Specifications

Form

Liquid

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General info

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Sequence similarities

Belongs to the CENP-P/CTF19 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
See full target information CENPP
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