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AB162993

Recombinant Human CEP55 protein (GST tag N-Terminus)

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Recombinant Human CEP55 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 464 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C10orf3, URCC6, CEP55, Centrosomal protein of 55 kDa, Cep55, Up-regulated in colon cancer 6

1 Images
SDS-PAGE - Recombinant Human CEP55 protein (GST tag N-Terminus) (AB162993)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CEP55 protein (GST tag N-Terminus) (AB162993)

ab162993 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q53EZ4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKASVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLLVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":464,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q53EZ4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CEP55 also known as centrosome-associated protein 55 or FLJ20808 is a protein with a molecular weight of about 55 kDa. This protein plays a mechanical role in cell division especially during cytokinesis. CEP55 primarily localizes at the centrosome and midbody of dividing cells. Its expression is widespread throughout various tissues though it is especially present in rapidly dividing or proliferating tissues.
Biological function summary

CEP55 contributes significantly to the final stages of cell division by acting as a critical regulator in cytokinesis. It participates in the abscission process which is the final separation phase of two daughter cells. CEP55 helps recruit other proteins necessary for this process functioning as part of a larger complex. This protein complex interaction ensures the correct division of cells and proper inheritance of cellular components.

Pathways

CEP55 plays an integral role in the ESCRT (Endosomal Sorting Complex Required for Transport) machinery which is important for membrane remodeling. It also integrates into the cell cycle pathway influencing the transition from mitosis to cytokinesis. CEP55 interacts with proteins like ALIX and TSG101 within these pathways facilitating appropriate signaling and structural assembly to ensure successful cell division.

CEP55 is associated with cancer development and progression due to its role in cell division. Overexpression or misregulation of CEP55 can lead to uncontrolled cell proliferation often seen in various malignancies. CEP55 is connected to proteins such as PLK1 which also partakes in regulating cell cycle checkpoints therefore forming a potential target for cancer therapeutics. Another condition tied to CEP55 is microcephaly a genetic disorder caused by impaired cell division during neuronal development.
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Specifications

Form

Liquid

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General info

Function

Plays a role in mitotic exit and cytokinesis (PubMed : 16198290, PubMed : 17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed : 17853893). Not required for microtubule nucleation (PubMed : 16198290). Plays a role in the development of the brain and kidney (PubMed : 28264986).

Post-translational modifications

There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Plays a role in mitotic exit and cytokinesis (PubMed : 16198290, PubMed : 17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed : 17853893). Not required for microtubule nucleation (PubMed : 16198290). Plays a role in the development of the brain and kidney (PubMed : 28264986).
See full target information CEP55
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