Recombinant Human CFA protein (Tag Free)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CFA target often referred to as Complement Factor A is a component of the immune system with significant mechanical functions. As an integral protein it forms part of the larger complement system responsible for host defense against pathogens. Although the exact mass varies depending on post-translational modifications typical forms range between 80-100 kDa. Expression of CFA occurs predominantly within the liver and it gets secreted into the bloodstream where it participates in immune responses.

Biological function summary

Complement Factor A participates in important immune defense processes activating the complement cascade that leads to pathogen elimination. It plays a role in the assembly of the C3 convertase complex which amplifies complement activation. Complement Factor A works in tandem with other components like C3 C4 and C5 enhancing opsonization and clearing pathogens. This connectivity within the immune response demonstrates its essential role in maintaining homeostasis and guarding against infectious agents.

Pathways

Complement Factor A integrates into the classical and lectin pathways of the complement system. These pathways activate complement through antibody-antigen complexes or microbial sugars respectively. In these pathways CFA associates with proteins such as Complement Factor B and C2 where it forms active enzymatic complexes. Such interactions allow effective progression of the signaling cascade leading to potentiated immune responses and pathogen clearance.

Anomalies in Complement Factor A activity relate to conditions like autoimmune disorders and hereditary angioedema. In autoimmune disorders overactivation may lead to tissue damage while reduced function can result in infections. The protein interconnects with proteins such as Complement C3 and C1 which also influence disease pathology. Understanding CFA's detailed role provides insights into mitigating complement-related disorders through targeted interventions.