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AB164948

Recombinant Human CGB5 protein

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Recombinant Human CGB5 protein is a Human Full Length protein, in the 1 to 165 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

CGB, CGB5, CGB8, CGB3, Choriogonadotropin subunit beta 3, Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta, CG-beta

1 Images
SDS-PAGE - Recombinant Human CGB5 protein (AB164948)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human CGB5 protein (AB164948)

ab164948 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P0DN86

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":165,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P0DN87","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CGB5 also known as chorionic gonadotropin subunit beta 5 is a protein closely related to the hormonal function in mammals. It belongs to the beta subunit of the human chorionic gonadotropin (hCG) hormone. This protein has a molecular mass of approximately 22 kDa and is expressed mainly in the placenta. Its expression is highly regulated during pregnancy contributing to various reproductive processes.
Biological function summary

The chorionic gonadotropin subunit beta 5 plays a significant role in supporting the uterine environment. It is a critical part of the larger glycoprotein hormone complex which includes the alpha subunit. This complex interacts with luteinizing hormone/chorionic gonadotropin receptors (LHCGR) in the ovary facilitating the maintenance of the corpus luteum and promoting progesterone production. This biological activity is important for successful embryonic implantation and maintenance of early pregnancy.

Pathways

CGB5 is integral to the reproductive and hormonal regulatory pathways. It actively participates in the gonadotropin-releasing hormone pathway which influences other key hormones involved in reproductive functions. Within this pathway CGB5 interacts with luteinizing hormone (LH) as both play critical roles in fertility and menstrual regulation processes.

CGB5 shows associations with trophoblastic diseases such as choriocarcinoma and other gestational trophoblastic diseases. Abnormal expression or mutations in CGB5 can result in gestational trophoblastic neoplasms. Its disease association is often understood alongside other proteins like CGB7 which share similar functions in the beta subunit family. Understanding these connections helps in targeted interventions and therapeutic strategies to manage related reproductive health issues.
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Specifications

Form

Liquid

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General info

Function

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

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Product protocols

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Target data

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
See full target information CGB3
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