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AB202195

Recombinant Human CGREF1 protein (His tag N-Terminus)

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Recombinant Human CGREF1 protein (His tag N-Terminus) is a Human Full Length protein, in the 20 to 301 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CGR11, CGREF1, Cell growth regulator with EF hand domain protein 1, Cell growth regulatory gene 11 protein, Hydrophobestin

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SDS-PAGE - Recombinant Human CGREF1 protein (AB202195)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CGREF1 protein (AB202195)

15% SDS-PAGE analysis of ab202195 (3ug).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q99674

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSAPKDGVTRPDSEVQHQLLPNPFQPGQEQLGLLQSYLKGLGRTEVQLEHLSREQVLLYLFALHDYDQSGQLDGLELLSMLTAALAPGAANSPTTNPVILIVDKVLETQDLNGDGLMTPAELINFPGVALRHVEPGEPLAPSPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDEI","proteinLength":"Full Length","predictedMolecularWeight":"32.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":301,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99674","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CGREF1 also known as Cell Growth Regulator with EF-Hand Domain 1 is a protein involved in cellular processes. It has a mass of approximately 33 kDa. CGREF1 is expressed in various tissues with considerable presence in the placenta and certain areas of the brain. Mechanically the protein contributes to cell adhesion and cell growth regulation possibly by interacting with other cell surface molecules and intracellular signaling pathways.
Biological function summary

CGREF1 is essential in maintaining cellular adhesion particularly in epithelial cells. It forms part of a larger complex involving calcium ions which are necessary for its adhesion-promoting activity. The ability of CGREF1 to foster stable intercellular connections supports tissue integrity and cellular communication. It may also influence the cell cycle and modulate cell proliferation.

Pathways

CGREF1 is linked with pathways involved in cell adhesion and signaling. A notable pathway includes the cell-cell adhesion pathway which integrates with cellular signaling to coordinate responses to cellular and environmental cues. CGREF1 may interact with proteins such as cadherins which are integral to adhesion processes and signal transduction.

CGREF1's role in cellular adhesion connects it to potential implications in cancer and developmental abnormalities. Aberrant expression or dysfunction of CGREF1 might contribute to metastasis in cancers by disrupting normal cell adhesion. Additionally its interaction with proteins like E-cadherin could play a part in disease pathology where alteration of adhesion and signaling pathways can lead to tumor progression and other disorders.
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Specifications

Form

Liquid

Additional notes

ab202195 was purified by using conventional chromatography.

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General info

Function

Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.

Post-translational modifications

Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.

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Product protocols

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Target data

Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
See full target information CGREF1
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