Recombinant Human CGREF1 protein is a Human Full Length protein, in the 20 to 301 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S A P K D G V T R P D S E V Q H Q L L P N P F Q P G Q E Q L G L L Q S Y L K G L G R T E V Q L E H L S R E Q V L L Y L F A L H D Y D Q S G Q L D G L E L L S M L T A A L A P G A A N S P T T N P V I L I V D K V L E T Q D L N G D G L M T P A E L I N F P G V A L R H V E P G E P L A P S P Q E P Q A V G R Q S L L A K S P L R Q E T Q E A P G P R E E A K G Q V E A R R E S L D P V Q E P G G Q A E A D G D V P G P R G E A E G Q A E A K G D A P G P R G E A G G Q A E A E G D A P G P R G E A G G Q A E A R E N G E E A K E L P G E T L E S K N T Q N D F E V H I V Q V E N D E I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
Alternative names
CGR11, CGREF1, Cell growth regulator with EF hand domain protein 1, Cell growth regulatory gene 11 protein, Hydrophobestin
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Recombinant Human CGREF1 protein is a Human Full Length protein, in the 20 to 301 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q99674-4
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S A P K D G V T R P D S E V Q H Q L L P N P F Q P G Q E Q L G L L Q S Y L K G L G R T E V Q L E H L S R E Q V L L Y L F A L H D Y D Q S G Q L D G L E L L S M L T A A L A P G A A N S P T T N P V I L I V D K V L E T Q D L N G D G L M T P A E L I N F P G V A L R H V E P G E P L A P S P Q E P Q A V G R Q S L L A K S P L R Q E T Q E A P G P R E E A K G Q V E A R R E S L D P V Q E P G G Q A E A D G D V P G P R G E A E G Q A E A K G D A P G P R G E A G G Q A E A E G D A P G P R G E A G G Q A E A R E N G E E A K E L P G E T L E S K N T Q N D F E V H I V Q V E N D E I
- Accession
- Q99674
- Protein length
- Full Length
- Predicted molecular weight
- 32.3 kDa
- Amino acids
- 20 to 301
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab202195 was purified by using conventional chromatography.
General info
- Function
Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
- Post-translational modifications
Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CGREF1 also known as Cell Growth Regulator with EF-Hand Domain 1 is a protein involved in cellular processes. It has a mass of approximately 33 kDa. CGREF1 is expressed in various tissues with considerable presence in the placenta and certain areas of the brain. Mechanically the protein contributes to cell adhesion and cell growth regulation possibly by interacting with other cell surface molecules and intracellular signaling pathways.
- Biological function summary
CGREF1 is essential in maintaining cellular adhesion particularly in epithelial cells. It forms part of a larger complex involving calcium ions which are necessary for its adhesion-promoting activity. The ability of CGREF1 to foster stable intercellular connections supports tissue integrity and cellular communication. It may also influence the cell cycle and modulate cell proliferation.
- Pathways
CGREF1 is linked with pathways involved in cell adhesion and signaling. A notable pathway includes the cell-cell adhesion pathway which integrates with cellular signaling to coordinate responses to cellular and environmental cues. CGREF1 may interact with proteins such as cadherins which are integral to adhesion processes and signal transduction.
- Associated diseases and disorders
CGREF1's role in cellular adhesion connects it to potential implications in cancer and developmental abnormalities. Aberrant expression or dysfunction of CGREF1 might contribute to metastasis in cancers by disrupting normal cell adhesion. Additionally its interaction with proteins like E-cadherin could play a part in disease pathology where alteration of adhesion and signaling pathways can lead to tumor progression and other disorders.
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1 product image
SDS-PAGE - Recombinant Human CGREF1 protein (ab202195)
15% SDS-PAGE analysis of ab202195 (3ug).
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