Recombinant Human CHAC2 protein
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Recombinant Human CHAC2 protein is a Human Full Length protein, in the 1 to 184 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Glutathione-specific gamma-glutamylcyclotransferase 2, Gamma-GCG 2, Cation transport regulator-like protein 2, CHAC2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CHAC2 protein (AB177655)
15% SDS-PAGE analysis of ab177655 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CHAC2 participates in the degradation of glutathione an essential antioxidant within cells. This protein forms part of a glutathione degradation complex helping to maintain cellular homeostasis by affecting oxidative stress response. By breaking down gamma-glutamyl bonds in glutathione CHAC2 influences many cellular functions such as cell proliferation and apoptosis.
Pathways
CHAC2 significantly impacts oxidative stress and apoptosis pathways. In these routes CHAC2's activity interlinks closely with the regulation of intracellular reactive oxygen species (ROS) levels. CHAC1 a homolog of CHAC2 shares similarities in the pathways suggesting a level of redundancy or cooperative functions between these proteins particularly in stress response mechanisms.
Specifications
Form
Liquid
Additional notes
ab177655 was purified using conventional chromatography.
General info
Function
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Sequence similarities
Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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