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AB182810

Recombinant Human CHAD protein

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Recombinant Human CHAD protein is a Human Full Length protein, in the 23 to 359 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

SLRR4A, CHAD, Chondroadherin, Cartilage leucine-rich protein

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

T7 tag N-Terminus His tag N-Terminus TEV tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

No

Accession

O15335

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHGNLYFQGGEFCPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDATCASPAKFKGQHIRDTDAFRSCKFPTKRSKKAGRH","proteinLength":"Full Length","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":359,"aminoAcidStart":23,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O15335","tags":[{"tag":"T7","terminus":"N-Terminus"},{"tag":"His","terminus":"N-Terminus"},{"tag":"TEV","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CHAD known as Chondroadherin is a protein that plays a mechanical role in cartilage structure. It has a molecular mass of approximately 38 kDa. You can find CHAD expressed mainly in cartilage tissues where it contributes to maintaining the integrity of the extracellular matrix. The protein interacts with other matrix components allowing it to help stabilize cartilage structure and function.
Biological function summary

CHAD takes part in cell adhesion and interaction within cartilage tissue. It does not typically form a complex with other proteins instead functioning by binding to collagen fibrils and integrins. This binding action promotes the linkage between cells and the extracellular matrix important for maintaining healthy cartilage. CHAD's role in cell adhesion underlines its importance in tissue-specific functions and structural support.

Pathways

CHAD functions within the cartilage development pathway specifically contributing to extracellular matrix organization. It interacts with proteins like collagen and integrins strengthening structural network essential for cartilage durability. Another relevant pathway is the integrin signaling pathway where CHAD influences cellular responses to mechanical stimuli aligning its role with tissue maintenance and repair processes.

CHAD relates closely to osteoarthritis a condition characterized by the degeneration of cartilage. The protein's interaction with collagen and integrins might influence cartilage resilience potentially affecting the progression of osteoarthritis. Moreover CHAD's presence and function also connect it to cartilage-related disorders encompassing its relationship with collagen and integrins both vital in maintaining cartilage health.
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Specifications

Form

Liquid

Additional notes

The final product was refolded using unique “temperature shift inclusion body refolding” technology and chromatographically purified.

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General info

Function

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.

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Product protocols

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Target data

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).
See full target information CHAD
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Product promise

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