Recombinant Human CHMP1B protein (His tag N-Terminus)
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(1 Publication)
Recombinant Human CHMP1B protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
C18orf2, CHMP1B, Charged multivesicular body protein 1b, CHMP1.5, Chromatin-modifying protein 1b, Vacuolar protein sorting-associated protein 46-2, CHMP1b, Vps46-2, hVps46-2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human CHMP1B protein (His tag N-Terminus) (AB126679)
15% SDS-PAGE showing ab126679 (3 µg). Please note : Molecular weight on SDS-PAGE will appear higher.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CHMP1B plays a significant role in the proper functioning of cellular processes involving vesicle trafficking and organelle biogenesis. It forms part of the ESCRT-III complex which facilitates the scission of membrane bud necks. This activity is vital for the final stages of cytokinesis as well as in the formation of multivesicular bodies. These functions contribute to maintaining cellular structure and homeostasis.
Pathways
CHMP1B is involved in the ESCRT pathway which is integral to endosomal sorting and membrane remodeling processes. This pathway associates closely with proteins like VPS4 which regulates the disassembly and recycling of ESCRT-III complexes. Additionally CHMP1B participates in the pathway of cytokinesis where it collaborates with proteins such as ALIX to ensure the successful separation of dividing cells.
Specifications
Form
Liquid
Additional notes
ab126679 is purified by using conventional chromatography techniques.
General info
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.
Sequence similarities
Belongs to the SNF7 family.
Subcellular localisation
Endosome
Target data
Publications (1)
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Frontiers in pharmacology 12:704040 PubMed34671253
2021
Applications
Unspecified application
Species
Unspecified reactive species
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