Recombinant Human Cholecystokinin protein is a Human Full Length protein, in the 1 to 115 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
M N S G V C L C V L M A V L A A G A L T Q P V P P A D P A G S G L Q R A E E A P R R Q L R V S Q R T D G E S R A H L G A L L A R Y I Q Q A R K A P S G R M S I V K N L Q N L D P S H R I S D R D Y M G W M D F G R R S A E E Y E Y P S
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Cholecystokinin, CCK, CCK
Recombinant Human Cholecystokinin protein is a Human Full Length protein, in the 1 to 115 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
M N S G V C L C V L M A V L A A G A L T Q P V P P A D P A G S G L Q R A E E A P R R Q L R V S Q R T D G E S R A H L G A L L A R Y I Q Q A R K A P S G R M S I V K N L Q N L D P S H R I S D R D Y M G W M D F G R R S A E E Y E Y P S
Full Length
1 to 115
Recombinant
GST tag N-Terminus
Liquid
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Belongs to the gastrin/cholecystokinin family.
The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
U+00A0;
U+00A0;
This supplementary information is collated from multiple sources and compiled automatically.
Cholecystokinin often referenced as CCK is a peptide hormone with a mass of approximately 8 kDa. It plays a mechanical role by being released from the I-cells in the small intestine particularly the duodenum. This release occurs in response to nutrients in the gut such as fats and proteins. Cholecystokinin acts by binding to its receptors CCK-A and CCK-B to execute its functions. In addition to the gut CCK is expressed in the central nervous system where it contributes to diverse neurological functions.
Beyond its presence in the digestive system cholecystokinin is important for stimulating digestive enzymes secretion from the pancreas and bile release from the gallbladder. This peptide is also part of the central nervous system where it influences appetite control satiety and anxiety regulation. While not part of a classic protein complex CCK interacts with various receptors and enzymes to perform its roles in these physiological processes.
Several important physiological pathways include cholecystokinin to regulate digestive processes and satiety signals. It is significant in the digestion pathway interacting chiefly with proteins such as trypsinogen and pancreatic lipase enhancing the breakdown of nutrients. In the neural pathway CCK influences neurotransmitter release including dopamine and serotonin highlighting its role in appetite suppression and mood regulation.
Cholecystokinin has been implicated in gastrointestinal and neurological conditions. It links to gallstone disease by influencing bile composition and flow which can affect the development of gallstones. Additionally CCK has connections to anxiety disorders given its impact on neurotransmitter systems within the brain. The peptide's engagement with CCK receptors makes it a target for studying these disorders as alterations in its signaling can contribute to disease pathology.
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ab158040 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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