Skip to main content

Recombinant Human Cholecystokinin protein is a Human Full Length protein, in the 1 to 115 aa range, expressed in Wheat germ and suitable for ELISA, WB.

Be the first to review this product! Submit a review

Images

SDS-PAGE - Recombinant Human Cholecystokinin protein (AB158040), expandable thumbnail

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

Biologically active

No

Amino acid sequence

M N S G V C L C V L M A V L A A G A L T Q P V P P A D P A G S G L Q R A E E A P R R Q L R V S Q R T D G E S R A H L G A L L A R Y I Q Q A R K A P S G R M S I V K N L Q N L D P S H R I S D R D Y M G W M D F G R R S A E E Y E Y P S

Reactivity data

Application

ELISA

Reactivity

Reacts

Dilution info

-

Notes

-

Application

WB

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Alternative names

Recommended products

Recombinant Human Cholecystokinin protein is a Human Full Length protein, in the 1 to 115 aa range, expressed in Wheat germ and suitable for ELISA, WB.

Key facts

Expression system

Wheat germ

Applications

ELISA, WB

Accession
P06307-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione

Sequence info

Amino acid sequence

M N S G V C L C V L M A V L A A G A L T Q P V P P A D P A G S G L Q R A E E A P R R Q L R V S Q R T D G E S R A H L G A L L A R Y I Q Q A R K A P S G R M S I V K N L Q N L D P S H R I S D R D Y M G W M D F G R R S A E E Y E Y P S

Accession

P06307

Protein length

Full Length

Amino acids

1 to 115

Nature

Recombinant

Tags

GST tag N-Terminus

Specifications

Form

Liquid

General info

Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Post-translational modifications

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

U+00A0;

U+00A0;

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cholecystokinin often referenced as CCK is a peptide hormone with a mass of approximately 8 kDa. It plays a mechanical role by being released from the I-cells in the small intestine particularly the duodenum. This release occurs in response to nutrients in the gut such as fats and proteins. Cholecystokinin acts by binding to its receptors CCK-A and CCK-B to execute its functions. In addition to the gut CCK is expressed in the central nervous system where it contributes to diverse neurological functions.

Biological function summary

Beyond its presence in the digestive system cholecystokinin is important for stimulating digestive enzymes secretion from the pancreas and bile release from the gallbladder. This peptide is also part of the central nervous system where it influences appetite control satiety and anxiety regulation. While not part of a classic protein complex CCK interacts with various receptors and enzymes to perform its roles in these physiological processes.

Pathways

Several important physiological pathways include cholecystokinin to regulate digestive processes and satiety signals. It is significant in the digestion pathway interacting chiefly with proteins such as trypsinogen and pancreatic lipase enhancing the breakdown of nutrients. In the neural pathway CCK influences neurotransmitter release including dopamine and serotonin highlighting its role in appetite suppression and mood regulation.

Associated diseases and disorders

Cholecystokinin has been implicated in gastrointestinal and neurological conditions. It links to gallstone disease by influencing bile composition and flow which can affect the development of gallstones. Additionally CCK has connections to anxiety disorders given its impact on neurotransmitter systems within the brain. The peptide's engagement with CCK receptors makes it a target for studying these disorders as alterations in its signaling can contribute to disease pathology.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • SDS-PAGE - Recombinant Human Cholecystokinin protein (ab158040), expandable thumbnail

    SDS-PAGE - Recombinant Human Cholecystokinin protein (ab158040)

    ab158040 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com