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AB276623

Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag)

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Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag) is a Human Full Length protein, in the 1 to 165 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CGB, CGB5, CGB8, CGB3, Choriogonadotropin subunit beta 3, Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta, CG-beta

1 Images
SDS-PAGE - Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag) (AB276623)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag) (AB276623)

SDS-PAGE analysis of ab276623

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P0DN86

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Proteins & Peptides

AB191924

Recombinant Human hCG beta protein

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  • 0
Primary Antibodies

AB317568

Anti-hCG beta antibody [EPR28726-38] - BSA and Azide free

Recombinant|RabMAb

Western blot - Anti-hCG beta antibody [EPR28726-38] - BSA and Azide free (AB317568)

  • 0
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Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

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Primary Antibodies

AB281562

Anti-FSH beta antibody [EPR24439-141]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSH beta antibody [EPR24439-141] (AB281562)

  • 3
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ","proteinLength":"Full Length","predictedMolecularWeight":"17 kDa","actualMolecularWeight":null,"aminoAcidEnd":165,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P0DN86","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Choriogonadotropin subunit beta 3 often known as beta hCG or hCG 2 is a vital protein component of the hormone human chorionic gonadotropin (hCG). This protein which has a mass of around 22-25 kDa is necessary for the reproductive process. Primarily expressed in the placental trophoblastic cells chorion and testicular germ cell tumors choriogonadotropin beta subunit plays an instrumental role in pregnancy maintenance and has become a useful marker in clinical diagnostics particularly in prenatal screenings and cancer assays.
Biological function summary

HCG 2 stimulates corpus luteum maintenance during early pregnancy promoting progesterone production which is essential for uterine lining support. The choriogonadotropin beta subunit forms a functional heterodimer with the alpha subunit sharing similarity with other glycoprotein hormone structures like luteinizing hormone (LH). The intact heterodimer acts at the LH/CG receptor revealing its bioactivity in reproductive tissues.

Pathways

The choriogonadotropin beta subunit participates in the reproductive hormone signaling pathways particularly in facilitating reproductive processes. It is closely related to proteins such as luteinizing hormone sharing pathways involved in gonadal steroidogenesis. This connection ensures the regulation of steroid hormones critical for reproduction and sexual development.

Choriogonadotropin beta subunit serves as a marker for conditions like gestational trophoblastic disease and testicular cancer. Abnormal levels of beta hCG indicate pathological states with links to ovarian and testicular tumor markers. Its role alongside other proteins like alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) aids in the diagnosis and monitoring of these malignancies.
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Specifications

Form

Lyophilized

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General info

Function

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

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Product protocols

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Target data

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
See full target information CGB3
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Product promise

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