Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag) is a Human Full Length protein, in the 1 to 165 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M E M F Q G L L L L L L L S M G G T W A S K E P L R P R C R P I N A T L A V E K E G C P V C I T V N T T I C A G Y C P T M T R V L Q G V L P A L P Q V V C N Y R D V R F E S I R L P G C P R G V N P V V S Y A V A L S C Q C A L C R R S T T D C G G P K D H P L T C D D P R F Q D S S S S K A P P P S L P S P S R L P G P S D T P I L P Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Alternative names
CGB, CGB5, CGB8, CGB3, Choriogonadotropin subunit beta 3, Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta, CG-beta
Recommended products
Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag) is a Human Full Length protein, in the 1 to 165 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P0DN86-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M E M F Q G L L L L L L L S M G G T W A S K E P L R P R C R P I N A T L A V E K E G C P V C I T V N T T I C A G Y C P T M T R V L Q G V L P A L P Q V V C N Y R D V R F E S I R L P G C P R G V N P V V S Y A V A L S C Q C A L C R R S T T D C G G P K D H P L T C D D P R F Q D S S S S K A P P P S L P S P S R L P G P S D T P I L P Q
- Accession
- P0DN86
- Protein length
- Full Length
- Predicted molecular weight
- 17 kDa
- Amino acids
- 1 to 165
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
- Sequence similarities
Belongs to the glycoprotein hormones subunit beta family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Choriogonadotropin subunit beta 3 often known as beta hCG or hCG 2 is a vital protein component of the hormone human chorionic gonadotropin (hCG). This protein which has a mass of around 22-25 kDa is necessary for the reproductive process. Primarily expressed in the placental trophoblastic cells chorion and testicular germ cell tumors choriogonadotropin beta subunit plays an instrumental role in pregnancy maintenance and has become a useful marker in clinical diagnostics particularly in prenatal screenings and cancer assays.
- Biological function summary
HCG 2 stimulates corpus luteum maintenance during early pregnancy promoting progesterone production which is essential for uterine lining support. The choriogonadotropin beta subunit forms a functional heterodimer with the alpha subunit sharing similarity with other glycoprotein hormone structures like luteinizing hormone (LH). The intact heterodimer acts at the LH/CG receptor revealing its bioactivity in reproductive tissues.
- Pathways
The choriogonadotropin beta subunit participates in the reproductive hormone signaling pathways particularly in facilitating reproductive processes. It is closely related to proteins such as luteinizing hormone sharing pathways involved in gonadal steroidogenesis. This connection ensures the regulation of steroid hormones critical for reproduction and sexual development.
- Associated diseases and disorders
Choriogonadotropin beta subunit serves as a marker for conditions like gestational trophoblastic disease and testicular cancer. Abnormal levels of beta hCG indicate pathological states with links to ovarian and testicular tumor markers. Its role alongside other proteins like alpha-fetoprotein (AFP) and lactate dehydrogenase (LDH) aids in the diagnosis and monitoring of these malignancies.
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SDS-PAGE - Recombinant Human Choriogonadotropin subunit beta 3 protein (His tag) (ab276623)
SDS-PAGE analysis of ab276623
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