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AB158120

Recombinant Human CHRNB4 protein (GST tag N-Terminus)

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Recombinant Human CHRNB4 protein (GST tag N-Terminus) is a Human Fragment protein, in the 68 to 177 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Neuronal acetylcholine receptor subunit beta-4, CHRNB4

1 Images
SDS-PAGE - Recombinant Human CHRNB4 protein (GST tag N-Terminus) (AB158120)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CHRNB4 protein (GST tag N-Terminus) (AB158120)

ab158120 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P30926

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Recombinant Human CHRNB3 protein (His tag)

SDS-PAGE - Recombinant Human CHRNB3 protein (His tag) (AB276651)

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Recombinant Human SOX17 protein (GST tag N-Terminus)

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Primary Antibodies

AB233735

Anti-CHRNB4 antibody [7F5B2]

Western blot - Anti-CHRNB4 antibody [7F5B2] (AB233735)

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Recombinant human IL-28B protein (His tag)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Nicotinic Acetylcholine Receptor beta 4.
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Sequence info

[{"sequence":"VNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYD","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":177,"aminoAcidStart":68,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P30926","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed : 20881005, PubMed : 31488329, PubMed : 8663494, PubMed : 8906617, PubMed : 9203638). CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed : 11118490, PubMed : 20881005, PubMed : 8663494). CHRNA3 : CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed : 31488329). CHRNA3 : CHRNB4 or CHRNA3 : CHRNA5 : CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3 : CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity).

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.

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Product protocols

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Target data

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed : 20881005, PubMed : 31488329, PubMed : 8663494, PubMed : 8906617, PubMed : 9203638). CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed : 11118490, PubMed : 20881005, PubMed : 8663494). CHRNA3 : CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed : 31488329). CHRNA3 : CHRNB4 or CHRNA3 : CHRNA5 : CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3 : CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity).
See full target information CHRNB4
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