Recombinant Human CIKS/ACT1 protein is a Human Full Length protein, in the 1 to 565 aa range, expressed in Wheat germ and suitable for ELISA, WB.
M N R S I P V E V D E S E P Y P S Q L L K P I P E Y S P E E E S E P P A P N I R N M A P N S L S A P T M L H N S S G D F S Q A H S T L K L A N H Q R P V S R Q V T C L R T Q V L E D S E D S F C R R H P G L G K A F P S G C S A V S E P A S E S V V G A L P A E H Q F S F M E K R N Q W L V S Q L S A A S P D T G H D S D K S D Q S L P N A S A D S L G G S Q E M V Q R P Q P H R N R A G L D L P T I D T G Y D S Q P Q D V L G I R Q L E R P L P L T S V C Y P Q D L P R P L R S R E F P Q F E P Q R Y P A C A Q M L P P N L S P H A P W N Y H Y H C P G S P D H Q V P Y G H D Y P R A A Y Q Q V I Q P A L P G Q P L P G A S V R G L H P V Q K V I L N Y P S P W D Q E E R P A Q R D C S F P G L P R H Q D Q P H H Q P P N R A G A P G E S L E C P A E L R P Q V P Q P P S P A A V P R P P S N P P A R G T L K T S N L P E E L R K V F I T Y S M D T A M E V V K F V N F L L V N G F Q T A I D I F E D R I R G I D I I K W M E R Y L R D K T V M I I V A I S P K Y K Q D V E G A E S Q L D E D E H G L H T K Y I H R M M Q I E F I K Q G S M N F R F I P V L F P N A K K E H V P T W L Q N T H V Y S W P K N K K N I L L R L L R E E E Y V A P P R G P L P T L Q V V P L
Application | Reactivity | Dilution info | Notes |
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Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).
C6orf2, C6orf4, C6orf5, C6orf6, TRAF3IP2, E3 ubiquitin ligase TRAF3IP2, Adapter protein CIKS, Connection to IKK and SAPK/JNK, E3 ubiquitin-protein ligase CIKS, Nuclear factor NF-kappa-B activator 1, TRAF3-interacting protein 2, ACT1
Recombinant Human CIKS/ACT1 protein is a Human Full Length protein, in the 1 to 565 aa range, expressed in Wheat germ and suitable for ELISA, WB.
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).
This product was previously labelled as CIKS.
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ab161141 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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