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AB160325

Recombinant Human Claudin 12 protein (GST tag N-Terminus)

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Recombinant Human Claudin 12 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 244 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Claudin-12, CLDN12

1 Images
SDS-PAGE - Recombinant Human Claudin 12 protein (GST tag N-Terminus) (AB160325)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Claudin 12 protein (GST tag N-Terminus) (AB160325)

ab160325 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P56749

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVVSHTT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":244,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P56749","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin 12 is a component of the tight junction proteins sometimes referred to as CLDN12. It is a small protein with a molecular mass approximately of 24 kDa. Claudin 12 is expressed particularly in epithelial tissues including the intestine and kidney where it contributes to the formation of tight junction strands. These strands regulate the paracellular transport and Claudin 12's specific role involves modulating permeability to ions and small molecules in these tissues.
Biological function summary

The protein Claudin 12 acts to maintain barrier functions in epithelial layers. As a member of the claudin family it participates in creating a selective permittivity barrier in the tight junction complex. This complex is essential for maintaining the separation between different bodily compartments and regulating the passage of various substances. Claudin 12 assists in preserving the ion balance and protecting tissue integrity against external factors.

Pathways

The protein Claudin 12 plays important roles in cellular signaling and homeostasis. It is involved in the tight junction signaling pathway where it interacts with other claudins such as Claudin 1 and Claudin 4. The protein contributes to the epithelial-to-mesenchymal transition (EMT) pathway impacting cellular adhesion and movement. These interactions allow cells to respond to changes in the environment supporting processes such as development and tissue repair.

Claudin 12 holds connections to various health conditions. Alterations in Claudin 12 expression and function are linked to disorders such as inflammatory bowel disease and cancer. In these conditions its relationship with Claudin 3 and occludin may influence barrier integrity and immune response. Understanding Claudin 12's role in disease can improve insights into epithelial-layer related disruptions and inform therapeutic strategies.
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Specifications

Form

Liquid

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General info

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Sequence similarities

Belongs to the claudin family.

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Product protocols

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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
See full target information Claudin-12
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Product promise

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