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AB235064

Recombinant Human Claudin 3 protein (Tagged)

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Recombinant Human Claudin 3 protein (Tagged) is a Human Fragment protein, in the 30 to 80 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

C7orf1, CPETR2, CLDN3, Claudin-3, Clostridium perfringens enterotoxin receptor 2, Rat ventral prostate.1 protein homolog, CPE-R 2, CPE-receptor 2, hRVP1

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SDS-PAGE - Recombinant Human Claudin 3 protein (Tagged) (AB235064)
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Supplier Data

SDS-PAGE - Recombinant Human Claudin 3 protein (Tagged) (AB235064)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab235064.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus B2M tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Primary Antibodies

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RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 3 antibody [EPR19971] (AB214487)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"RVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAAR","proteinLength":"Fragment","predictedMolecularWeight":"19.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":80,"aminoAcidStart":30,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O15551","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"B2M","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein 'Claudin 3' also known simply as Claudin-3 or CLDN3 is an important component of tight junctions in epithelial and endothelial cells. Claudin 3 has a molecular weight of approximately 22 kDa. It is expressed in a variety of tissues including the liver lungs and kidneys. By forming channels within tight junctions Claudin 3 regulates paracellular transport and maintains the barrier properties of cell layers thereby playing a significant role in preserving cellular environments.
Biological function summary

Claudin 3 contributes to the establishment and function of tight junctions that create a selective barrier in epithelial cell layers. This protein works as part of a larger complex consisting of other claudin family members which together ensure the integrity and permeability of the barrier. Through these complexes Claudin 3 helps facilitate cell polarity and tissue homeostasis which are essential for normal cellular function and organization.

Pathways

Claudin 3 participates in signaling pathways such as the Wnt/beta-catenin pathway and the epidermal growth factor receptor (EGFR) pathway. Claudin 3 modulates these pathways alongside other claudin proteins and partners like zonula occludens proteins. These interactions are central to processes like tissue morphogenesis and wound healing where precise control of cellular communication and migration is required.

Claudin 3 is linked to various cancers including ovarian and prostate cancer. Its expression is often altered in tumor cells where its dysregulation can lead to the disruption of tight junctions and contribute to cancer progression. In ovarian cancer Claudin 3 interacts with matrix metalloproteinases (MMPs) influencing the metastatic potential of cancer cells. Understanding Claudin 3's role can provide insights into new therapeutic targets for managing epithelial barrier dysfunction in cancer.
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General info

Function

Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Sequence similarities

Belongs to the claudin family.

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Product protocols

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Target data

Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
See full target information CLDN3
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