Recombinant Human CLEC-2 protein (denatured) is a Human Fragment protein, in the 55 to 229 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S S V M Q R N Y L Q G E N E N R T G T L Q Q L A K R F C Q Y V V K Q S E L K G T F K G H K C S P C D T N W R Y Y G D S C Y G F F R H N L T W E E S K Q Y C T D M N A T L L K I D N R N I V E Y I K A R T H L I R W V G L S R Q K S N E V W K W E D G S V I S E N M F E F L E D G K G N M N C A Y F H N G K M H P T F C E N K H Y L M C E R K A G M T K V D Q L P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Alternative names
CLEC2, UNQ721/PRO1384, CLEC1B, C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC-2
Recommended products
Recombinant Human CLEC-2 protein (denatured) is a Human Fragment protein, in the 55 to 229 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9P126-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.24% Tris buffer
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S S V M Q R N Y L Q G E N E N R T G T L Q Q L A K R F C Q Y V V K Q S E L K G T F K G H K C S P C D T N W R Y Y G D S C Y G F F R H N L T W E E S K Q Y C T D M N A T L L K I D N R N I V E Y I K A R T H L I R W V G L S R Q K S N E V W K W E D G S V I S E N M F E F L E D G K G N M N C A Y F H N G K M H P T F C E N K H Y L M C E R K A G M T K V D Q L P
- Accession
- Q9P126
- Protein length
- Fragment
- Predicted molecular weight
- 23.1 kDa
- Amino acids
- 55 to 229
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab202622 was purified by conventional chromatography techniques.
General info
- Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).
- Post-translational modifications
Glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human CLEC-2 protein (denatured) (ab202622)
15% SDS-PAGE analysis of ab202622 (3 μg)
Downloads
Product protocols
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