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AB202622

Recombinant Human CLEC-2 protein (denatured) (His tag N-Terminus)

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Recombinant Human CLEC-2 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 55 to 229 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

CLEC2, UNQ721/PRO1384, CLEC1B, C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC-2

1 Images
SDS-PAGE - Recombinant Human CLEC-2 protein (denatured) (His tag N-Terminus) (AB202622)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CLEC-2 protein (denatured) (His tag N-Terminus) (AB202622)

15% SDS-PAGE analysis of ab202622 (3 μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9P126

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.24% Tris buffer

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSSVMQRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP","proteinLength":"Fragment","predictedMolecularWeight":"23.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":229,"aminoAcidStart":55,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9P126","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab202622 was purified by conventional chromatography techniques.

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General info

Function

C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed : 18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed : 18955485).. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed : 16174766, PubMed : 18955485).. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed : 16940507).

Post-translational modifications

Glycosylated.. Phosphorylated on tyrosine residue in response to rhodocytin binding.

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Product protocols

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Target data

C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed : 18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed : 18955485).. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed : 16174766, PubMed : 18955485).. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed : 16940507).
See full target information CLEC1B
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