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AB276395

Recombinant Human CLEC4D protein (His tag)

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Recombinant Human CLEC4D protein (His tag) is a Human Fragment protein, in the 52 to 215 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD368, CLECSF8, MCL, CLEC4D, C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, Dendritic cell-associated C-type lectin 3, CLEC-6, DC-associated C-type lectin 3, Dectin-3

1 Images
SDS-PAGE - Recombinant Human CLEC4D protein (His tag) (AB276395)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CLEC4D protein (His tag) (AB276395)

SDS-PAGE analysis of ab276395

Key facts

Purity

>92% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8WXI8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Recombinant Human CLEC10A protein

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Primary Antibodies

AB175021

Anti-CLEC4D antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4D antibody (AB175021)

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AB276403

Recombinant Human VSIG2 protein (His tag)

SDS-PAGE - Recombinant Human VSIG2 protein (His tag) (AB276403)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN","proteinLength":"Fragment","predictedMolecularWeight":"21.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":215,"aminoAcidStart":52,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8WXI8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Lyophilized

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General info

Function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed : 23602766, PubMed : 23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed : 23602766, PubMed : 23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed : 23602766, PubMed : 23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed : 23911656). Functions as an endocytic receptor (PubMed : 14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed : 14971047).

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Product protocols

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Target data

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed : 23602766, PubMed : 23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed : 23602766, PubMed : 23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed : 23602766, PubMed : 23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed : 23911656). Functions as an endocytic receptor (PubMed : 14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed : 14971047).
See full target information CLEC4D
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