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AB104744

Recombinant Human CLIC4 protein

5

(1 Review)

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(1 Publication)

Recombinant Human CLIC4 protein is a Human Full Length protein, in the 1 to 253 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Chloride intracellular channel protein 4, Glutaredoxin-like oxidoreductase CLIC4, Intracellular chloride ion channel protein p64H1, CLIC4

1 Images
SDS-PAGE - Recombinant Human CLIC4 protein (AB104744)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CLIC4 protein (AB104744)

15% SDS-PAGE (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9Y696

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK","proteinLength":"Full Length","predictedMolecularWeight":"30.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":253,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y696","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab104744 is purified using conventional chromatography techniques.

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General info

Function

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed : 25581026, PubMed : 37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed : 16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3.

Sequence similarities

Belongs to the chloride channel CLIC family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed : 25581026, PubMed : 37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed : 16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3.
See full target information CLIC4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Circulation research 124:52-65 PubMed30582444

2018

CLIC4/Arf6 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Vahitha B Abdul-Salam,Giusy Russomanno,Chen Chien-Nien,Abdul S Mahomed,Luke A Yates,Martin R Wilkins,Lan Zhao,Magdalena Gierula,Oliver Dubois,Ute Schaeper,Jens Endruschat,Beata Wojciak-Stothard
View all publications
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Product promise

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