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AB114706

Recombinant Human CLK1 protein

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Recombinant Human CLK1 protein is a Human Full Length protein, in the 1 to 484 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

CLK, CLK1, Dual specificity protein kinase CLK1, CDC-like kinase 1

1 Images
SDS-PAGE - Recombinant Human CLK1 protein (AB114706)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CLK1 protein (AB114706)

12.5% SDS-PAGE showing ab114706 at approximately 79.31 kDa stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

P49759

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
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Sequence info

[{"sequence":"MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI","proteinLength":"Full Length","predictedMolecularWeight":"79.31 kDa","actualMolecularWeight":null,"aminoAcidEnd":484,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P49759","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates : SRSF1, SRSF3 and PTPN1 (PubMed : 10480872, PubMed : 19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed : 19168442).

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.

Post-translational modifications

Autophosphorylates on all three types of residues.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates : SRSF1, SRSF3 and PTPN1 (PubMed : 10480872, PubMed : 19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed : 19168442).
See full target information CLK1
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Complementary Products

Primary Antibodies

AB74044

Anti-CLK1 antibody

Western blot - Anti-CLK1 antibody (AB74044)

  • 3
  • 2
Cell Lines & Lysates

AB265448

Human CLK1 knockout HeLa cell line

Sanger Sequencing - Human CLK1 knockout HeLa cell line (AB265448)

  • 0
  • 0
Primary Antibodies

AB229831

Anti-COSMC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COSMC antibody (AB229831)

  • 0
  • 0
Biochemicals

AB120220

D4476, CK1 inhibitor

Chemical Structure - D4476, CK1 inhibitor (AB120220)

  • 0
  • 0

Product promise

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