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AB169887

Recombinant Human Collagen VI alpha 2 protein

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Recombinant Human Collagen VI alpha 2 protein is a Human Fragment protein, in the 820 to 1019 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Collagen alpha-2(VI) chain, COL6A2

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His-T7 tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P12110

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHGNLYFQGGETELSVAQCTQRPVDIVFLLDGSERLGEQNFHKARRFVEQVARRLTLARRDDDPLNARVALLQFGGPGEQQVAFPLSHNLTAIHEALETTQYLNSFSHVGAGVVHAINAIVRSPRGRARRHAELSFVFLTDGVTGNDSLHESAHSMRKQNVVPTVLALGSDVDMDVLTTLSLGDRAAVFHEKDYDSLAQPGFFDRFIRWIC","proteinLength":"Fragment","predictedMolecularWeight":"25.32 kDa","actualMolecularWeight":null,"aminoAcidEnd":1019,"aminoAcidStart":820,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P12110","tags":[{"tag":"His-T7","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Collagen VI alpha 2 also known as COL6A2 or anti-collagen VI is a protein that is an essential component of the extracellular matrix. It forms a part of the collagen VI complex which is important for connective tissue stability and function. COL6A2 has a molecular mass of approximately 130 kDa. It is widely expressed in various tissues including muscle skin and the basement membrane of blood vessels indicating its diverse functional role.
Biological function summary

The COL6A2 protein contributes to maintaining tissue integrity and resilience. It forms a beaded filament structure as part of a collagen VI tetramer when combined with other alpha chains (alpha 1 and alpha 3). These interactions at the molecular level help to provide tensile strength and structural support to many tissues especially in muscle where it impacts elasticity and repair mechanisms.

Pathways

COL6A2 and its associated complex participate in the extracellular matrix organization and cell adhesion pathways. In these processes it interacts with proteins such as integrins and laminins which are important for cellular attachment and communication. Such pathways underline the significant roles COL6A2 plays in maintaining normal tissue architecture and cellular environments.

The COL6A2 protein has strong associations with conditions like myosclerosis and Bethlem myopathy. Mutations or dysfunctions in the COL6A2 gene can disrupt the extracellular matrix leading to musculoskeletal disorders. It also shows interactions with other proteins like dystrophin in these pathological states emphasizing its involvement in muscular integrity and function.
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Specifications

Form

Liquid

Additional notes

The final product was refolded using a unique “temperature shift inclusion body refolding” technology and chromatographically purified.

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General info

Function

Collagen VI acts as a cell-binding protein.

Sequence similarities

Belongs to the type VI collagen family.

Post-translational modifications

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

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Product protocols

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Target data

Collagen VI acts as a cell-binding protein.
See full target information Collagen alpha-2(VI) chain
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Product promise

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