JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276736

Recombinant Human Contactin 6 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Contactin 6 protein is a Human Fragment protein, in the 1 to 999 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6

1 Images
SDS-PAGE - Recombinant Human Contactin 6 protein (AB276736)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Contactin 6 protein (AB276736)

SDS-PAGE analysis of ab276736

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UQ52

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MRLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSS","proteinLength":"Fragment","predictedMolecularWeight":"135.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":999,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9UQ52","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Contactin 6 also known as CNTN6 is a neural cell adhesion molecule that plays an important role in the communication and interconnection of nerve cells. This protein has a molecular weight of approximately 110 kDa and belongs to the immunoglobulin superfamily. Contactin 6 is highly expressed in the central nervous system especially in the brain regions such as the cerebellum and hippocampus. It facilitates the formation of axonal connections and supports the proper functioning of neural circuits influencing synaptic stability and plasticity.
Biological function summary

Contactin 6 contributes significantly to the development and maintenance of the nervous system. This protein often interacts with other cell adhesion molecules forming complexes that mediate cell-cell interactions necessary for neuronal patterning and guidance. It regulates axon growth and helps in establishing precise neural networks. Through these connections Contactin 6 plays a role in developmental processes that affect neuronal migration and differentiation.

Pathways

Contactin 6 participates in neural development and signaling pathways. One important pathway is the cell adhesion pathway where Contactin 6 interacts with proteins like L1CAM and NrCAM essential for axonal guidance and synaptogenesis. Another pathway involves its association with the Notch signaling pathway which influences neurogenic outcomes and fate specification during embryonic development. These interactions highlight its importance in neural connectivity and signaling.

Contactin 6 has been linked to neurodevelopmental disorders and autism spectrum disorders (ASD). Alterations in CNTN6 expression or mutations might disrupt neurodevelopment and lead to cognitive impairments. The protein interacts with autism-related proteins such as CASPR2 influencing synaptic connectivity that might underpin these disorders. Furthermore some studies suggest an association with attention deficit hyperactivity disorder (ADHD) where similar pathways and protein interactions contribute to symptomatology and neurological development issues.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).

Sequence similarities

Belongs to the immunoglobulin superfamily. Contactin family.

style
left-column

Product protocols

style
left-column

Target data

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).
See full target information CNTN6
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB272678

Anti-CLN6 antibody

Western blot - Anti-CLN6 antibody (AB272678)

  • 0
  • 0
Primary Antibodies

AB224596

Anti-Contactin 6 antibody

Western blot - Anti-Contactin 6 antibody (AB224596)

  • 0
  • 0
Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
Proteins & Peptides

AB276694

Recombinant Human ATP1B2 protein (His tag)

SDS-PAGE - Recombinant Human ATP1B2 protein (His tag) (AB276694)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com