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AB107148

Recombinant Human COPZ1 protein

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Recombinant Human COPZ1 protein is a Human Full Length protein, in the 1 to 177 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

COPZ, CGI-120, HSPC181, COPZ1, Coatomer subunit zeta-1, Zeta-1-coat protein, Zeta-1 COP

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SDS-PAGE - Recombinant Human COPZ1 protein (AB107148)
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SDS-PAGE - Recombinant Human COPZ1 protein (AB107148)

15% SDS-PAGE showing ab107148 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P61923

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR","proteinLength":"Full Length","predictedMolecularWeight":"22.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":177,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P61923","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COPZ1 also known as coatomer subunit zeta-1 is a protein subunit of the coatomer complex involved in forming the COPI vesicles which are important for transport in cellular processes. This protein has a molecular mass of about 19.1 kDa. COPZ1 is expressed in various tissues with higher expression observed in certain epithelial tissues. It facilitates the proliferation and maintenance of the Golgi apparatus by participating in retrograde Golgi-to-ER transport.
Biological function summary

COPZ1 is part of the coatomer protein complex which is essential for vesicular trafficking. The complex plays an important role in maintaining Golgi structure and function by recycling proteins back to the endoplasmic reticulum. COPZ1 functions within this complex to ensure that cellular components are transported effectively influencing secretion and cell surface receptor cycling processes.

Pathways

COPZ1 takes part in intracellular trafficking networks specifically the COPI-mediated transport pathway. This pathway includes coatomer protein complexes like COPB1 and COPB2 which work alongside COPZ1. It is involved with the retrograde transport of proteins from the Golgi to the ER impacting overall cellular homeostasis and secretion pathways.

COPZ1 has connections to cancer cell proliferation processes. Its expression levels can affect tumor growth and it is linked to certain cancer types such as breast cancer. COPZ1's interaction with proteins like ARF1 which influences vesicle formation plays a role in oncogenic pathways by potentially altering cellular motility and invasiveness in tumor environments.
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Specifications

Form

Liquid

Additional notes

ab107148 is purified using conventional chromatography techniques.

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General info

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).

Sequence similarities

Belongs to the adaptor complexes small subunit family.

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Product protocols

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Target data

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
See full target information COPZ1
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Complementary Products

Primary Antibodies

AB236670

Anti-COPZ1 antibody

Western blot - Anti-COPZ1 antibody (AB236670)

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