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AB276471

Recombinant Human COQ7 protein (His tag)

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Recombinant Human COQ7 protein (His tag) is a Human Fragment protein, in the 37 to 217 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

DMQ hydroxylase, Timing protein clk-1 homolog, Ubiquinone biosynthesis monooxygenase COQ7, COQ7

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SDS-PAGE - Recombinant Human COQ7 protein (His tag) (AB276471)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human COQ7 protein (His tag) (AB276471)

SDS-PAGE analysis of ab276471

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q99807

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"SGMTLDNISRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLWNVLGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFRDEELEHHDIGLDHDAELAPAYAVLKSIIQAGCRVAIYLSERL","proteinLength":"Fragment","predictedMolecularWeight":"21.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":217,"aminoAcidStart":37,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q99807","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COQ7 also known as 5-demethoxyubiquinone hydroxylase is a mitochondrial protein with a molecular mass of about 24 kDa. It plays an important role in the biosynthesis of coenzyme Q (CoQ) also known as ubiquinone by catalyzing the hydroxylation of demethoxyubiquinone. COQ7 has a conserved role across different species and is expressed in various tissues most abundantly in organs with high energy demands like the heart and liver.
Biological function summary

COQ7 is a part of the multi-subunit complex of proteins responsible for the CoQ biosynthesis pathway. It acts as a hydroxylase and contributes to the final stages of coenzyme Q production. CoQ is essential for electron transport in the mitochondrial respiratory chain which plays a critical function in cellular energy production.

Pathways

Demethoxyubiquinone hydroxylase activity of COQ7 plays a significant role in the mitochondrial electron transport chain and the mevalonate pathway. This protein interacts with other COQ proteins such as COQ6 and COQ9 forming a complex that ensures the completion of the biosynthesis of CoQ. These pathways are key to maintaining proper mitochondrial function and energy production within the cell.

COQ7 dysregulation connects to conditions like CoQ10 deficiency and ataxia. Variants in COQ7 can affect CoQ production leading to potential disruptions in mitochondrial function. It may also interact with proteins like COX10 involved in oxidative phosphorylation disorders highlighting its role in maintaining mitochondrial integrity. These connections highlight the importance of COQ7 in health and disease contexts.
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Specifications

Form

Lyophilized

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General info

Function

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (PubMed : 28409910). Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (PubMed : 25961505).

Sequence similarities

Belongs to the COQ7 family.

Subcellular localisation

Mitochondrion inner membrane

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Product protocols

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Target data

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (PubMed : 28409910). Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (PubMed : 25961505).
See full target information COQ7
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