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AB202604

Recombinant Human COQ9 protein (His tag N-Terminus)

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Recombinant Human COQ9 protein (His tag N-Terminus) is a Human Full Length protein, in the 45 to 318 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C16orf49, HSPC326, PSEC0129, COQ9

1 Images
SDS-PAGE - Recombinant Human COQ9 protein (AB202604)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human COQ9 protein (AB202604)

15% SDS-PAGE analysis of 3 μg of ab202604.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O75208

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSRSSDEQKQQPPNSFSQQHSETQGAEKPDPESSHSPPRYTDQGGEEEEDYESEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR","proteinLength":"Full Length","predictedMolecularWeight":"33.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":318,"aminoAcidStart":45,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75208","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

COQ9 also known as coenzyme Q9 homolog is a protein integral to coenzyme Q (ubiquinone) biosynthesis. It has a molecular mass of approximately 30 kDa. COQ9 expresses mainly in mitochondria the energy centers of cells. This localization aligns with its role in the mitochondrial respiratory chain where it assists in ubiquinone production essential for electron transport and ATP generation.
Biological function summary

COQ9 operates within a multi-subunit complex called the CoQ biosynthesis complex. This complex supports the synthesis of coenzyme Q10 a molecule involved in cellular respiration. COQ9's function ensures the stability and efficiency of the CoQ biosynthesis process which is necessary for mitochondrial health and energy production. Its role is supported by interactions with other proteins in the complex fostering effective biosynthesis of this quinone compound.

Pathways

The COQ9 protein is an important player in the ubiquinone biosynthesis pathway and indirectly influences the electron transport chain. COQ9 associates closely with other COQ proteins such as COQ8 which collectively drive the coenzyme Q production essential for the electron transport chain's proper function. Defects in this pathway can disrupt cellular energy metabolism highlighting COQ9's significance.

Dysfunctions in COQ9 relate to conditions like primary coenzyme Q10 deficiency and mitochondrial encephalomyopathies. These disorders stem from inadequate coenzyme Q10 production leading to impaired mitochondrial function. COQ9 deficiencies can involve COQ2 mutations as both proteins participate in coenzyme Q10 biosynthesis further linking COQ9 to these pathological states.
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Specifications

Form

Liquid

Additional notes

ab202604 was purified using conventional chromatography techniques.

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General info

Function

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.

Sequence similarities

Belongs to the COQ9 family.

Post-translational modifications

In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121).

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.
See full target information COQ9
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