Recombinant Human Corin protein is a Human Fragment protein, in the 616 to 715 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
Amino acid sequence
C K E R D L W E C P S N K Q C L K H T V I C D G F P D C P D Y M D E K N C S F C Q D D E L E C A N H A C V S R D L W C D G E A D C S D S S D E W D C V T L S I N V N S S S F L M V H R A A T E H H V C A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity).Isoform 2has weaker endopeptidase activity compared to isoform 1.
Alternative names
Atrial natriuretic peptide-converting enzyme, Corin, Heart-specific serine proteinase ATC2, Pro-ANP-converting enzyme, Transmembrane protease serine 10, CRN, CORIN, TMPRSS10
Recommended products
Recombinant Human Corin protein is a Human Fragment protein, in the 616 to 715 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Alternative names
Atrial natriuretic peptide-converting enzyme, Corin, Heart-specific serine proteinase ATC2, Pro-ANP-converting enzyme, Transmembrane protease serine 10, CRN, CORIN, TMPRSS10
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
- Accession
- Q9Y5Q5-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
C K E R D L W E C P S N K Q C L K H T V I C D G F P D C P D Y M D E K N C S F C Q D D E L E C A N H A C V S R D L W C D G E A D C S D S S D E W D C V T L S I N V N S S S F L M V H R A A T E H H V C A
- Accession
- Protein length
Fragment
- Amino acids
616 to 715
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity).
- Sequence similarities
Belongs to the peptidase S1 family.
- Post-translational modifications
N-glycosylated; required for processing and activation.
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
U+00A0;
U+00A0;
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1 product image
SDS-PAGE - Recombinant Human Corin protein (ab153116)
ab153116 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Product protocols
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