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Recombinant Human Corin protein is a Human Fragment protein, in the 616 to 715 aa range, expressed in Wheat germ and suitable for ELISA, WB.

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Images

SDS-PAGE - Recombinant Human Corin protein (AB153116), expandable thumbnail

Key facts

Expression system
Wheat germ
Tags
GST tag N-Terminus
Applications
ELISA, WB
Biologically active
No

Amino acid sequence

C K E R D L W E C P S N K Q C L K H T V I C D G F P D C P D Y M D E K N C S F C Q D D E L E C A N H A C V S R D L W C D G E A D C S D S S D E W D C V T L S I N V N S S S F L M V H R A A T E H H V C A

Reactivity data

Application
ELISA
Reactivity
Reacts
Dilution info
-
Notes

-

Application
WB
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

Function

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). Isoform 2. Has weaker endopeptidase activity compared to isoform 1.

Alternative names

Recommended products

Recombinant Human Corin protein is a Human Fragment protein, in the 616 to 715 aa range, expressed in Wheat germ and suitable for ELISA, WB.

Key facts

Expression system
Wheat germ
Applications
ELISA, WB
Accession
Q9Y5Q5-1
Animal free
No
Species
Human
Concentration
Loading...
Storage buffer

pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione

Sequence info

Amino acid sequence

C K E R D L W E C P S N K Q C L K H T V I C D G F P D C P D Y M D E K N C S F C Q D D E L E C A N H A C V S R D L W C D G E A D C S D S S D E W D C V T L S I N V N S S S F L M V H R A A T E H H V C A
Accession
Q9Y5Q5
Protein length
Fragment
Amino acids
616 to 715
Nature
Recombinant
Tags
GST tag N-Terminus

Specifications

Form
Liquid

General info

Function

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity).

Sequence similarities

Belongs to the peptidase S1 family.

Post-translational modifications

N-glycosylated; required for processing and activation.

Storage

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • SDS-PAGE - Recombinant Human Corin protein (ab153116), expandable thumbnail

    SDS-PAGE - Recombinant Human Corin protein (ab153116)

    ab153116 on a 12.5% SDS-PAGE stained with Coomassie Blue.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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