Recombinant Human coronavirus SARS-CoV-2 PLpro protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The PLpro protein functions by cleaving the viral polyprotein at specific sites to generate non-structural proteins essential for replication. It forms part of a larger multi-functional complex within the viral replication machinery. This protease also counteracts host immune responses by deubiquitinating host proteins and modifying immune signaling molecules therefore suppressing antiviral signaling pathways. PLpro's activities not only support viral replication but also aid in the manipulation of host cell functions to benefit the virus.

Pathways

PLpro engages in viral replication and immune evasion pathways. It involves itself primarily in the viral replication transcription complex that SARS-CoV-2 depends on. By cleaving the viral polyprotein it works closely with the main protease Mpro another key protease essential for processing the viral polypeptides. Furthermore PLpro's deubiquitinating activity interferes with the host's innate immune signaling pathways which impacts the function of proteins like interferon regulatory factors (IRFs) that are important for mounting an effective antiviral response.