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Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) is a Fragment protein, in the 685 to 1211 aa range, expressed in HEK 293, with >90% purity, < 1 EU/mL endotoxin level and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) (AB272106), expandable thumbnail
  • Western blot - Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) (AB272106), expandable thumbnail
  • Western blot - Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) (AB272106), expandable thumbnail
  • Indirect ELISA - Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) (AB272106), expandable thumbnail
  • Indirect ELISA - Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) (AB272106), expandable thumbnail

Publications

Key facts

Purity
>90%
Endotoxin level
< 1 EU/mL
Expression system
HEK 293 cells
Tags
Fc tag C-Terminus
Applications
SDS-PAGE
Biologically active
No

Amino acid sequence

T Q T N S P R R A R S V A S Q S I I A Y T M S L G A E N S V A Y S N N S I A I P T N F T I S V T T E I L P V S M T K T S V D C T M Y I C G D S T E C S N L L L Q Y G S F C T Q L N R A L T G I A V E Q D K N T Q E V F A Q V K Q I Y K T P P I K D F G G F N F S Q I L P D P S K P S K R S F I E D L L F N K V T L A D A G F I K Q Y G D C L G D I A A R D L I C A Q K F N G L T V L P P L L T D E M I A Q Y T S A L L A G T I T S G W T F G A G A A L Q I P F A M Q M A Y R F N G I G V T Q N V L Y E N Q K L I A N Q F N S A I G K I Q D S L S S T A S A L G K L Q D V V N Q N A Q A L N T L V K Q L S S N F G A I S S V L N D I L S R L D K V E A E V Q I D R L I T G R L Q S L Q T Y V T Q Q L I R A A E I R A S A N L A A T K M S E C V L G Q S K R V D F C G K G Y H L M S F P Q S A P H G V V F L H V T Y V P A Q E K N F T T A P A I C H D G K A H F P R E G V F V S N G T H W F V T Q R N F Y E P Q I I T T D N T F V S G N C D V V I G I V N N T V Y D P L Q P E L D S F K E E L D K Y F K N H T S P D V D L G D I S G I N A S V V N I Q K E I D R L N E V A K N L N E S L I D L Q E L G K Y E Q Y I K

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

Additional Targets

SARS-CoV-2 Spike Glycoprotein S2

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Recombinant Human coronavirus SARS-CoV-2 Spike Glycoprotein S2 (Fc Chimera) is a Fragment protein, in the 685 to 1211 aa range, expressed in HEK 293, with >90% purity, < 1 EU/mL endotoxin level and suitable for SDS-PAGE.

Key facts

Purity
>90%
Endotoxin level
< 1 EU/mL
Expression system
HEK 293 cells
Applications
SDS-PAGE
Animal free
No
Concentration
Loading...
Storage buffer

pH: 7 - 8
Constituents: PBS

Sequence info

Amino acid sequence

T Q T N S P R R A R S V A S Q S I I A Y T M S L G A E N S V A Y S N N S I A I P T N F T I S V T T E I L P V S M T K T S V D C T M Y I C G D S T E C S N L L L Q Y G S F C T Q L N R A L T G I A V E Q D K N T Q E V F A Q V K Q I Y K T P P I K D F G G F N F S Q I L P D P S K P S K R S F I E D L L F N K V T L A D A G F I K Q Y G D C L G D I A A R D L I C A Q K F N G L T V L P P L L T D E M I A Q Y T S A L L A G T I T S G W T F G A G A A L Q I P F A M Q M A Y R F N G I G V T Q N V L Y E N Q K L I A N Q F N S A I G K I Q D S L S S T A S A L G K L Q D V V N Q N A Q A L N T L V K Q L S S N F G A I S S V L N D I L S R L D K V E A E V Q I D R L I T G R L Q S L Q T Y V T Q Q L I R A A E I R A S A N L A A T K M S E C V L G Q S K R V D F C G K G Y H L M S F P Q S A P H G V V F L H V T Y V P A Q E K N F T T A P A I C H D G K A H F P R E G V F V S N G T H W F V T Q R N F Y E P Q I I T T D N T F V S G N C D V V I G I V N N T V Y D P L Q P E L D S F K E E L D K Y F K N H T S P D V D L G D I S G I N A S V V N I Q K E I D R L N E V A K N L N E S L I D L Q E L G K Y E Q Y I K
Accession
Protein length
Fragment
Predicted molecular weight
86 kDa
Amino acids
685 to 1211
Nature
Recombinant
Tags
Fc tag C-Terminus

Specifications

Form
Liquid

Storage

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The SARS-CoV-2 Spike Glycoprotein S2 also known as S2 subunit is a segment of spike protein found on the surface of the SARS-CoV-2 virus. The spike protein facilitates viral entry into host cells. Mechanically S2 mediates membrane fusion which is essential for the virus to merge with cellular membranes allowing viral RNA to enter and replicate within the host. This protein has a molecular weight of approximately 680 kDa combined with S1. Expressed mainly in virions the spike protein is the target for many therapeutic interventions.

Biological function summary

The SARS-CoV-2 Spike Glycoprotein S2 plays an important role in the viral infectivity process. It is part of a trimeric spike protein complex which undergoes a conformational shift during host cell entry. The S2 subunit specifically triggers the fusion process following receptor binding of another component the S1 subunit. During infection immune response typically generates anti-spike antibodies that target this protein aiming to block viral invasion or clear infected cells.

Pathways

The SARS-CoV-2 Spike Glycoprotein S2 is critical in the viral entry and replication pathway. It interacts with host proteins in pathways involving endocytosis. The fusion activity of S2 is closely associated with cellular proteases like TMPRSS2 and furin which prime the spike protein for entry. These interactions are important for the initiation of the viral replication cycle and help shape the host's pathophysiological response to infection.

Associated diseases and disorders

The SARS-CoV-2 Spike Glycoprotein S2 holds significant relevance in COVID-19 pathogenesis which is caused by the SARS-CoV-2 virus. This protein's interaction with angiotensin-converting enzyme 2 (ACE2) alongside the spike S1 subunit plays an important role in determining the virus’s infectivity and host cell invasion. Understanding its role can aid in designing therapeutic strategies against COVID-19 and related variants also revealing connections to host immune responses.

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