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AB270834

Recombinant Human coronavirus SARS E2 protein (Tagged)

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Recombinant Human coronavirus SARS E2 protein (Tagged) is a Fragment protein, in the 1 to 76 aa range, expressed in Escherichia coli, with >95%, suitable for ELISA, WB, SDS-PAGE.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag C-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Animal free

No

Carrier free

No

Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine), 0.8% Tris HCl, 0.35% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>May appear as multiple bands on SDS-PAGE (intact protein at 34.7 kDa, GST fusion protein at 26 kDa and the E fragment at 8.7 kDa).</p>" } } }
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Product details

Immunoreactive with SARS positive sera.
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"34.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":76,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":null,"tags":[{"tag":"GST","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SARS E2 protein also known as the envelope or E protein is a structural component of the SARS coronavirus. It has a molecular mass of about 8.4 kDa. The E2 protein is expressed on the envelope of the SARS coronavirus where it plays an important role in virus assembly budding and pathogenesis. This protein assists in the formation of the viral envelope by interacting with other viral components and host cell membranes facilitating the release of new virions from the host cell.
Biological function summary

The SARS E2 protein functions in the assembly of virions and is part of a larger viral protein complex. This protein is involved in the regulation of the host's intracellular membrane trafficking which impacts viral replication and release. The E2 protein exhibits ion channel activity known as a viroporin influencing various host cellular processes including stress response and apoptosis.

Pathways

The SARS E2 protein interacts with early endosomal and Golgi pathways which are critical for viral trafficking within the host cell. It shares functional relations with other SARS coronavirus proteins such as the M (membrane) and S (spike) proteins. These interactions allow the virus to efficiently package and release infectious particles. The E2 protein also influences pathways associated with inflammation and immune evasion contributing to the virus's ability to persist and cause disease.

The SARS E2 protein is directly associated with severe acute respiratory syndrome (SARS) and coronavirus disease (COVID-19). Its interaction with the host cell's pathways can exacerbate inflammation and immune dysfunction leading to severe respiratory symptoms. Connections exist between the E2 protein and proteins involved in the host's inflammatory response such as cytokines which can result in a cytokine storm a critical factor in disease progression and severity in SARS and COVID-19 patients.
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Specifications

Form

Liquid

Additional notes

GS-4B Sepharose-Affinity Purification.

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General info

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Product protocols

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Target data

See full target information SARS E2
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