Recombinant Human COUP TF1 protein is a Human Full Length protein, in the 1 to 423 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M A M V V S S W R D P Q D D V A G G N P G G P N P A A Q A A R G G G G G A G E Q Q Q Q A G S G A P H T P Q T P G Q P G A P A T P G T A G D K G Q G P P G S G Q S Q Q H I E C V V C G D K S S G K H Y G Q F T C E G C K S F F K R S V R R N L T Y T C R A N R N C P I D Q H H R N Q C Q Y C R L K K C L K V G M R R E A V Q R G R M P P T Q P N P G Q Y A L T N G D P L N G H C Y L S G Y I S L L L R A E P Y P T S R Y G S Q C M Q P N N I M G I E N I C E L A A R L L F S A V E W A R N I P F F P D L Q I T D Q V S L L R L T W S E L F V L N A A Q C S M P L H V A P L L A A A G L H A S P M S A D R V V A F M D H I R I F Q E Q V E K L K A L H V D S A E Y S C L K A I V L F T S D A C G L S D A A H I E S L Q E K S Q C A L E E Y V R S Q Y P N Q P S R F G K L L L R L P S L R T V S S S V I E Q L F F V R L V G K T P I E T L I R D M L L S G S S F N W P Y M S I Q C S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
Alternative names
EAR3, ERBAL3, TFCOUP1, NR2F1, COUP transcription factor 1, COUP-TF1, COUP transcription factor I, Nuclear receptor subfamily 2 group F member 1, V-erbA-related protein 3, COUP-TF I, EAR-3
Recommended products
Recombinant Human COUP TF1 protein is a Human Full Length protein, in the 1 to 423 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P10589-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A M V V S S W R D P Q D D V A G G N P G G P N P A A Q A A R G G G G G A G E Q Q Q Q A G S G A P H T P Q T P G Q P G A P A T P G T A G D K G Q G P P G S G Q S Q Q H I E C V V C G D K S S G K H Y G Q F T C E G C K S F F K R S V R R N L T Y T C R A N R N C P I D Q H H R N Q C Q Y C R L K K C L K V G M R R E A V Q R G R M P P T Q P N P G Q Y A L T N G D P L N G H C Y L S G Y I S L L L R A E P Y P T S R Y G S Q C M Q P N N I M G I E N I C E L A A R L L F S A V E W A R N I P F F P D L Q I T D Q V S L L R L T W S E L F V L N A A Q C S M P L H V A P L L A A A G L H A S P M S A D R V V A F M D H I R I F Q E Q V E K L K A L H V D S A E Y S C L K A I V L F T S D A C G L S D A A H I E S L Q E K S Q C A L E E Y V R S Q Y P N Q P S R F G K L L L R L P S L R T V S S S V I E Q L F F V R L V G K T P I E T L I R D M L L S G S S F N W P Y M S I Q C S
- Accession
- P10589
- Protein length
- Full Length
- Predicted molecular weight
- 72.6 kDa
- Amino acids
- 1 to 423
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
- Sequence similarities
Belongs to the nuclear hormone receptor family. NR2 subfamily.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
COUP TF1 also known as COUP-TFI COUP-TF1 COUPF protein COUP 70 and counter COUP functions as a transcription factor. It belongs to the nuclear receptor family of proteins and has a molecular mass of approximately 47 kDa. This protein expresses in a variety of tissues including the central nervous system heart and developing organs. It plays a role in regulating gene expression through binding to DNA sequences ultimately controlling developmental processes and cellular differentiation.
- Biological function summary
COUP TF1 influences numerous systems by regulating genes involved in neuronal development and organogenesis. This protein is a core component of transcription complexes interacting with other nuclear receptors and co-regulators to modulate its effects. The activity of COUP TF1 also extends to the regulation of neuronal subtype specification and synaptic connectivity signifying its importance in the central nervous system development.
- Pathways
COUP TF1 participates in essential signaling cascades such as the Notch and retinoic acid pathways. It modulates the retinoic acid response by interacting with the retinoic acid receptor (RAR) thereby influencing cell differentiation and growth. Additionally COUP TF1 interacts with the Notch signaling pathway affecting neural lineage decisions and maintenance. Its link to other transcription factors and receptors highlights its integrative role in various cellular contexts.
- Associated diseases and disorders
COUP TF1 alterations associate with cognitive and developmental disorders. Its dysregulation is implicated in conditions like mental retardation and schizophrenia. The protein's connection to disorders often involves its interaction with other proteins and signaling pathways such as those linked to neural development. COUP TF1's interplay with the retinoic acid receptor influences neurological traits and misregulation can contribute to disease progression.
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1 product image
SDS-PAGE - Recombinant Human COUP TF1 protein (ab152739)
12.5% SDS-PAGE analysis of ab152739 stained with Coomassie Blue.
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