Recombinant Human Coxsackie Adenovirus Receptor/hCAR protein is a Human Fragment protein, in the 20 to 237 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
L S I T T P E E M I E K A K G E T A Y L P C K F T L S P E D Q G P L D I E W L I S P A D N Q K V D Q V I I L Y S G D K I Y D D Y Y P D L K G R V H F T S N D L K S G D A S I N V T N L Q L S D I G T Y Q C K V K K A P G V A N K K I H L V V L V K P S G A R C Y V D G S E E I G S D F K I K C E P K E G S L P L Q Y E W Q K L S D S Q K M P T S W L A E M T S S V I S V K N A S S E Y S G T Y S C T V R N R V G S D Q C L L R L N V V P P S N K A G V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
CAR, CXADR, Coxsackievirus and adenovirus receptor, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR
Recombinant Human Coxsackie Adenovirus Receptor/hCAR protein is a Human Fragment protein, in the 20 to 237 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 7.2
Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride
Purtiy is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
N-glycosylated.
This product was previously labelled as Coxsackie Adenovirus Receptor
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