Recombinant Human CPEB1 protein - BSA and Azide free (denatured) (His tag N-Terminus)
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Recombinant Human CPEB1 protein - BSA and Azide free (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 561 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
CPEB, CPEB1, Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, h-CPEB, hCPEB-1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CPEB1 protein - BSA and Azide free (denatured) (His tag N-Terminus) (AB180313)
15% SDS-PAGE analysis of ab180313 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CPEB1 regulates cell cycle progression synaptic plasticity and gametogenesis. This protein sometimes part of larger ribonucleoprotein complexes acts by coordinating the temporal and spatial translation of target mRNAs. In neurons CPEB1 plays a significant role in the regulation of local protein synthesis impacting synaptic function and plasticity. In reproductive biology it influences oocyte maturation by modulating the translation of mRNAs important for meiotic progression.
Pathways
CPEB1 plays critical roles within pathways associated with long-term potentiation and the cell cycle. In the long-term potentiation pathway CPEB1 works alongside proteins such as eIF2α to enhance synaptic strength and memory formation. In cell cycle regulation CPEB1 affects the translational activation of cyclins thereby controlling the progression through the cell cycle phases. These pathways highlight its involvement in maintaining cellular homeostasis and response to external stimuli.
Specifications
Form
Liquid
General info
Function
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed : 24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed : 26398195).
Sequence similarities
Belongs to the RRM CPEB family.
Post-translational modifications
Phosphorylated on serine/threonine residues by AURKA within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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