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AB164250

Recombinant Human CPEB4 protein

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Recombinant Human CPEB4 protein is a Human Full Length protein, in the 1 to 322 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1673, CPEB4, Cytoplasmic polyadenylation element-binding protein 4, CPE-BP4, CPE-binding protein 4, hCPEB-4

1 Images
SDS-PAGE - Recombinant Human CPEB4 protein (AB164250)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human CPEB4 protein (AB164250)

ab164250 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q17RY0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MHSLESSLIDIMRAENDTIKGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":322,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q17RY0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CPEB4 also known as Cytoplasmic Polyadenylation Element Binding Protein 4 plays an important role in post-transcriptional regulation specifically in mRNA polyadenylation. This protein with a molecular weight of about 75 kDa is part of the CPEB family. Researchers have discovered its expression in various tissues including the brain and testes where it binds mRNA to control translation during processes like oocyte maturation and synaptic plasticity.
Biological function summary

The protein influences gene expression by modulating mRNA stability and translational efficiency. CPEB4 is not isolated in function; it interacts with other proteins as a part of the cytoplasmic polyadenylation complex. Through these interactions CPEB4 affects cell cycle progression stress responses and neuronal development therefore integrating environmental signals into cellular responses.

Pathways

The function of CPEB4 fits into critical signaling routes including the MAPK and PI3K-AKT pathways. Within these pathways CPEB4 interacts with proteins like MEK and AKT impacting cell survival growth and differentiation. The protein modulates mRNA translation in response to signaling cues serving as a conduit for transmitting intracellular messages that dictate cellular adaptation and response.

Researchers have linked CPEB4 to conditions such as cancer and neurodegenerative diseases. In glioblastoma for example the protein's aberrant expression affects tumorigenesis pathways often in conjunction with proteins like P53 to manipulate cell proliferation and survival. In neurodegenerative conditions alterations in CPEB4 can impact proteins involved in synaptic maintenance thereby contributing to cognitive decline and neural dysfunction.
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Specifications

Form

Liquid

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General info

Function

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed : 24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed : 24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed : 26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed : 22138752). Stimulates proliferation of melanocytes (PubMed : 27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Sequence similarities

Belongs to the RRM CPEB family.

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Product protocols

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Target data

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed : 24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed : 24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed : 26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed : 22138752). Stimulates proliferation of melanocytes (PubMed : 27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).
See full target information CPEB4
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