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AB156722

Recombinant Human CPPED1 protein (His tag N-Terminus)

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Recombinant Human CPPED1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CSTP1, CPPED1, Serine/threonine-protein phosphatase CPPED1, Calcineurin-like phosphoesterase domain-containing protein 1, Complete S-transactivated protein 1

1 Images
SDS-PAGE - Recombinant Human CPPED1 protein (His tag N-Terminus) (AB156722)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CPPED1 protein (His tag N-Terminus) (AB156722)

15% SDS-PAGE analysis of ab156722 (3 μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9BRF8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSAAEAGGVFHRARGRTLAAFPAEKESEWKGPFYFILGADPQFGLIKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPHGLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK","proteinLength":"Full Length","predictedMolecularWeight":"37.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BRF8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CPPED1 or calcineurin-like phosphoesterase domain containing 1 is an enzyme that plays a role in dephosphorylating phosphorylated serine and threonine residues. The protein has a molecular mass of approximately 39 kDa and localizes primarily in the cytoplasm. Expression of CPPED1 occurs mainly in tissues such as the liver kidney and heart. It affects cellular processes by modulating the phosphorylation status of specific substrates.
Biological function summary

This enzyme influences glucose metabolism and insulin signaling important functions for maintaining energy homeostasis. CPPED1 does not form part of a larger complex but acts on its own to regulate activities. Research indicates it has involvement in the regulation of metabolic pathways which may affect how cells respond to glucose and insulin.

Pathways

Scientists have linked CPPED1 to the insulin signaling pathway and glucose homeostasis pathway. It influences proteins within these pathways modulating phosphorylation levels which affects the function and regulation of metabolic processes. Closely related proteins such as protein kinase Akt and GSK-3β also play roles in these pathways interacting directly or indirectly with CPPED1's function and contributing to cellular energy regulation.

Alterations in CPPED1 activity connect to diabetes and metabolic syndrome both conditions relating to impaired glucose regulation. Studies have shown that shifts in CPPED1 expression or activity can disrupt normal metabolic processes leading to insulin resistance and associated disorders. The protein's function relates to other proteins like insulin receptor substrate (IRS) and AMPK which are involved in these diseases. Understanding CPPED1's role may provide insights into new therapeutic targets for diabetes management.

Specifications

Form

Liquid

Additional notes

ab156722 is purified using conventional chromatography techniques.

General info

Function

Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

Sequence similarities

Belongs to the metallophosphoesterase superfamily. CPPED1 family.

Product protocols

Target data

Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
See full target information CPPED1

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