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AB276666

Recombinant Human CPVL protein (His tag)

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Recombinant Human CPVL protein (His tag) is a Human Full Length protein, in the 1 to 476 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

VLP, PSEC0124, UNQ197/PRO223, CPVL, Probable serine carboxypeptidase CPVL, Vitellogenic carboxypeptidase-like protein, VCP-like protein, hVLP

1 Images
SDS-PAGE - Recombinant Human CPVL protein (His tag) (AB276666)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CPVL protein (His tag) (AB276666)

SDS-PAGE analysis of ab276666

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9H3G5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVGAMWKVIVSLVLLMPGPCDGLFRSLYRSVSMPPKGDSGQPLFLTPYIEAGKIQKGRELSLVGPFPGLNMKSYAGFLTVNKTYNSNLFFWFFPAQIQPEDAPVVLWLQGGPGGSSMFGLFVEHGPYVVTSNMTLRDRDFPWTTTLSMLYIDNPVGTGFSFTDDTHGYAVNEDDVARDLYSALIQFFQIFPEYKNNDFYVTGESYAGKYVPAIAHLIHSLNPVREVKINLNGIAIGDGYSDPESIIGGYAEFLYQIGLLDEKQKKYFQKQCHECIEHIRKQNWFEAFEILDKLLDGDLTSDPSYFQNVTGCSNYYNFLRCTEPEDQLYYVKFLSLPEVRQAIHVGNQTFNDGTIVEKYLREDTVQSVKPWLTEIMNNYKVLIYNGQLDIIVAAALTERSLMGMDWKGSQEYKKAEKKVWKIFKSDSEVAGYIRQAGDFHQVIIRGGGHILPYDQPLRAFDMINRFIYGKGWDPYVG","proteinLength":"Full Length","predictedMolecularWeight":"53.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":476,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H3G5","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CPVL stands for Carboxypeptidase Vitellogenic-Like and it functions as a serine carboxypeptidase involved in protein degradation processes. Also known by the name serine carboxypeptidase vitellogenic-like CPVL has a molecular mass of approximately 54 kDa. It is expressed mainly in macrophages and monocytes which are important components in the body's immune system. The enzyme plays a role in breaking down cellular proteins as part of normal cellular maintenance and defense mechanisms.
Biological function summary

CPVL contributes to the catabolism of proteins within immune cells aiding in the removal of peptides generated from cellular turnover and antigen processing. As part of the larger molecular complex of proteasomes and other proteolytic systems it participates in maintaining intracellular protein homeostasis. CPVL's activity supports the immune response by processing phosphoproteins and contributing to antigen presentation therefore influencing immune surveillance and response to pathogens.

Pathways

CPVL functions in key biological routes such as protein degradation and immune system regulation processes. Within these pathways CPVL interacts with other peptidases and proteolytic enzymes including the ubiquitin-proteasome system. This interaction highlights its role in managing protein quality control and influencing processes related to inflammation pathways. CPVL might work alongside other proteases like cathepsin L in these pathways emphasizing their coordinated roles in protein catabolism.

CPVL has connections to inflammatory diseases such as atherosclerosis and certain autoimmune conditions. Abnormal expression or mutation of CPVL could lead to altered macrophage function contributing to these conditions' pathogenesis. The protein also interacts in disease contexts with factors like interleukin-6 a cytokine implicated in inflammatory responses. These links suggest CPVL's importance in understanding inflammatory disease mechanisms and potential therapeutic strategies.
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Specifications

Form

Lyophilized

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General info

Function

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Sequence similarities

Belongs to the peptidase S10 family.

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Product protocols

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Target data

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
See full target information CPVL
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