Recombinant Human Creatine kinase B type protein

Specifications

Form

Liquid

Additional notes

Purified by conventional chromatography techniques.

General info

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed : 8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle : localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).

Sequence similarities

Belongs to the ATP:guanido phosphotransferase family.

Post-translational modifications

Ubiquitinated by the ECS(ASB9) complex, leading to its degradation by the proteasome.