Recombinant Human CRELD1 protein (His tag) is a Human Fragment protein, in the 1 to 362 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A P W P P K G L V P A M L W G L S L F L N L P G P I W L Q P S P P P Q S S P P P Q P H P C H T C R G L V D S F N K G L E R T I R D N F G G G N T A W E E E N L S K Y K D S E T R L V E V L E G V C S K S D F E C H R L L E L S E E L V E S W W F H K Q Q E A P D L F Q W L C S D S L K L C C P A G T F G P S C L P C P G G T E R P C G G Y G Q C E G E G T R G G S G H C D C Q A G Y G G E A C G Q C G L G Y F E A E R N A S H L V C S A C F G P C A R C S G P E E S N C L Q C K K G W A L H H L K C V D I D E C G T E G A N C G A D Q F C V N T E G S Y E C R D C A K A C L G C M G A G P G R C K K C S P G Y Q Q V G S K C L D V D E C E T E V C P G E N K Q C E N T E G G Y R C I C A E G Y K Q M E G I C V K E Q I P E S A G F F S E M T E D E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
Alternative names
CIRRIN, UNQ188/PRO214, CRELD1, Protein disulfide isomerase CRELD1, Cysteine-rich with EGF-like domain protein 1
Recommended products
Recombinant Human CRELD1 protein (His tag) is a Human Fragment protein, in the 1 to 362 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q96HD1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A P W P P K G L V P A M L W G L S L F L N L P G P I W L Q P S P P P Q S S P P P Q P H P C H T C R G L V D S F N K G L E R T I R D N F G G G N T A W E E E N L S K Y K D S E T R L V E V L E G V C S K S D F E C H R L L E L S E E L V E S W W F H K Q Q E A P D L F Q W L C S D S L K L C C P A G T F G P S C L P C P G G T E R P C G G Y G Q C E G E G T R G G S G H C D C Q A G Y G G E A C G Q C G L G Y F E A E R N A S H L V C S A C F G P C A R C S G P E E S N C L Q C K K G W A L H H L K C V D I D E C G T E G A N C G A D Q F C V N T E G S Y E C R D C A K A C L G C M G A G P G R C K K C S P G Y Q Q V G S K C L D V D E C E T E V C P G E N K Q C E N T E G G Y R C I C A E G Y K Q M E G I C V K E Q I P E S A G F F S E M T E D E
- Accession
- Q96HD1
- Protein length
- Fragment
- Predicted molecular weight
- 37.4 kDa
- Amino acids
- 1 to 362
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
- Sequence similarities
Belongs to the CRELD family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CRELD1 also known as cysteine-rich with EGF-like domains 1 is a protein implicated in cell-cell interactions or signaling mechanisms. This protein has an approximate molecular mass of 57.5 kDa. It is known for its expression in the heart specifically in the outflow tract during embryonic development and also in other tissues such as the kidney and lung. CRELD1 plays a role in various cellular processes important for normal organ development and function.
- Biological function summary
CRELD1 is involved in the structural assembly of the extracellular matrix. It is part of a complex that contributes to cellular adhesion and possibly enhances communication between cells. This protein's activity appears important for cardiac tissue development particularly in the forming of the cardiac septum and valvular structures. CRELD1 facilitates interactions that support proper organogenesis.
- Pathways
CRELD1 associates with both the Notch signaling pathway and the Wnt signaling pathway indicative of its role in developmental signaling events. Within the Notch pathway CRELD1 interacts with other proteins like Jagged and Delta facilitating critical embryonic development signals. Meanwhile in the Wnt pathway CRELD1's involvement further highlights its role in regulating cellular proliferation and differentiation processes which are essential during development.
- Associated diseases and disorders
CRELD1 has shown associations with congenital heart defects particularly atrioventricular septal defects (AVSD). Mutations in the CRELD1 gene have been linked to altered heart structure and function. Additionally research indicates that CRELD1 possibly interacts with proteins like TGFB3 in the context of heart development disorders where disruptions in signaling can cause developmental defects. Understanding these interactions assists in elucidating pathways that lead to such congenital anomalies.
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1 product image
SDS-PAGE - Recombinant Human CRELD1 protein (His tag) (ab276537)
SDS-PAGE analysis of ab276537
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