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AB152064

Recombinant Human CRHBP protein

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Recombinant Human CRHBP protein is a Human Full Length protein, in the 25 to 322 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

CRFBP, CRHBP, Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

P24387

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.5 Constituents: 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"YLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGLVDHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"34.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":322,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P24387","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRHBP also known as Corticotropin-Releasing Hormone Binding Protein plays a role in regulating the activity of corticotropin-releasing hormone (CRH) by binding to it with high affinity. The binding protein has a molecular mass of approximately 37 kDa. It is mainly found in the brain and pituitary gland. CRHBP controls the actions of CRH by sequestering it preventing CRH from interacting with its receptors. This modulation is essential for maintaining the balance of CRH's activity.
Biological function summary

CRHBP modulates the stress response by binding to CRH and limiting its availability to CRHR1 and CRHR2 receptors. By doing so it reduces the downstream signaling that would be induced by free CRH which affects the release of adrenocorticotropic hormone (ACTH) from the pituitary. This regulation is important for controlling how the body responds to stress. CRHBP does not form a larger protein complex but operates by interacting directly with CRH in the extracellular space.

Pathways

CRHBP functions within the hypothalamic-pituitary-adrenal (HPA) axis which plays an important role in the body's response to stress. By regulating CRH availability CRHBP indirectly influences the cortisol production pathway. This is important because cortisol is an important hormone in modulating metabolism and immune responses. Furthermore CRHBP interactions connect it to CRH which also communicates with other stress-related proteins such as CRHR1 and CRHR2 influencing their activity within the HPA axis.

CRHBP has been linked to conditions such as depression and anxiety disorders. The protein's role in regulating stress responses makes it relevant for understanding these conditions. Changes in CRHBP expression or function may alter CRH availability impacting mood regulation and psychological resilience. Additionally CRH the ligand for CRHBP is implicated in these disorders by influencing pathways that affect emotional behavior and stress tolerance.
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Specifications

Form

Lyophilized

Additional notes

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

Sequence similarities

Belongs to the CRF-binding protein family.

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Product protocols

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Target data

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
See full target information CRHBP
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