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AB126677

Recombinant Human CRIPT protein

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Recombinant Human CRIPT protein is a Human Full Length protein, in the 1 to 101 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

HSPC139, CRIPT, Cysteine-rich PDZ-binding protein, Cysteine-rich interactor of PDZ three, Cysteine-rich interactor of PDZ3

1 Images
SDS-PAGE - Recombinant Human CRIPT protein (AB126677)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human CRIPT protein (AB126677)

15% SDS-PAGE analysis of 3µg ab126677.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9P021

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMVCEKCEKKLGTVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV","proteinLength":"Full Length","predictedMolecularWeight":"13.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":101,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9P021","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRIPT or Cysteine-Rich PDZ-Binding Protein plays an important part in cellular signaling pathways through its interaction with other proteins containing PDZ domains. CRIPT has a mass of around 9 kDa. Researchers commonly express CRIPT in the central nervous system particularly in neurons where it helps in maintaining synaptic function.
Biological function summary

CRIPT interacts within the PSD-95 complex a multiprotein complex vital for synaptic signaling. CRIPT strongly binds to the PDZ domains of the PSD-95 family proteins contributing to the structural organization of postsynaptic density. This interaction supports important neurological processes influencing synaptic plasticity and stabilization.

Pathways

CRIPT has key roles in both the NMDA receptor signaling and the actin cytoskeleton organization pathways. CRIPT collaborates with proteins like PSD-95 and GRIP to optimize receptor clustering and signal transduction across the synapse. These interactions affect synaptic strength and plasticity impacting learning and memory processes.

CRIPT involvement connects it to neurological conditions such as schizophrenia and Alzheimer's disease. Alterations in CRIPT function can impact synaptic function which has been observed in these disorders. Researchers have linked CRIPT function alongside proteins like β-catenin and PSD-95 highlighting its importance in maintaining neuronal communication and integrity.
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Specifications

Form

Liquid

Additional notes

ab126677 was purified using conventional chromatography.

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General info

Function

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity).

Sequence similarities

Belongs to the CRIPT family.

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Product protocols

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Target data

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity).
See full target information CRIPT
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