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AB276349

Recombinant Human CRISP3 protein (His tag)

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Recombinant Human CRISP3 protein (His tag) is a Human Full Length protein, in the 1 to 245 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Cysteine-rich secretory protein 3, CRISP-3, Specific granule protein of 28 kDa, SGP28, CRISP3

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SDS-PAGE - Recombinant Human CRISP3 protein (His tag) (AB276349)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CRISP3 protein (His tag) (AB276349)

SDS-PAGE analysis of ab276349

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P54108

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY","proteinLength":"Full Length","predictedMolecularWeight":"26.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":245,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P54108","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRISP3 also known as Cysteine-Rich Secretory Protein 3 is a protein key in various physiological processes. It typically weighs about 28 kDa. Found in a range of tissues but most prominently in the salivary glands pancreas and prostate. Researchers also detect CRISP3 in neutrophils. Its secretion to the extracellular environment after synthesis helps facilitate its functional roles. Scientists use ELISA assays to quantify its expression.
Biological function summary

CRISP3 participates in host defense mechanisms and inflammation. It is a part of antimicrobial complexes that safeguard the body against microbial invasion. This protein can bind to other molecules and disrupt microbial membranes. It is believed to be involved in the innate immune response. CRISP3 also appears in granules of neutrophils where it functions during pathogen encounters.

Pathways

CRISP3 interacts in immune response pathways that help buffer the body against pathogenic challenges. It aligns with the immune system's defense activities and might impact the signaling and regulatory pathways of inflammation. CRISP3's interactions with other proteins like defensins enhance its role in these immune pathways.

CRISP3 shows potential involvement in prostate cancer and Sjögren's syndrome. Its overexpression associates with prostate cancer progression and alterations in its levels might affect cancer-related proteins like PSA (prostate-specific antigen). In the context of Sjögren's syndrome CRISP3's expression changes may link to saliva secretion dysregulation impacting mucosal defense and inflammatory proteins involved in the disorder.
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Specifications

Form

Lyophilized

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General info

Sequence similarities

Belongs to the CRISP family.

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Product protocols

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Target data

See full target information Cysteine-rich secretory protein 3
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Product promise

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