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AB162534

Recombinant Human CRLF3 protein (GST tag N-Terminus)

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Recombinant Human CRLF3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 442 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

CREME9, CRLM9, CYTOR4, P48, CRLF3, Cytokine receptor-like factor 3, Cytokine receptor-like molecule 9, Cytokine receptor-related protein 4, Type I cytokine receptor-like factor p48, CREME-9

1 Images
SDS-PAGE - Recombinant Human CRLF3 protein (GST tag N-Terminus) (AB162534)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CRLF3 protein (GST tag N-Terminus) (AB162534)

ab162534 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8IUI8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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SDS-PAGE - Recombinant Human WASF3 protein (GST tag N-Terminus) (AB161165)

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SDS-PAGE - Recombinant Human VNN3 protein (GST tag N-Terminus) (AB163077)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":442,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8IUI8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRLF3 also known as Cytokine Receptor-Like Factor 3 is a protein that acts within the cytokine receptor family. This target is involved in transmitting signals through the cell membrane. CRLF3 has a mass of approximately 50 kDa. Expression of CRLF3 occurs in a variety of tissues indicating its widespread role in cellular communication. The receptor plays a role in cytokine signaling which influences immune responses and cellular growth processes.
Biological function summary

CRLF3 contributes significantly to immune system function and neurodevelopment. It participates in forming receptor complexes necessary for signal transduction impacting various physiological processes. Studies have shown that CRLF3 participates in neuroimmune pathways linking neural and immune system activities. Researchers often explore its mechanism alongside related receptors such as those in the interleukin receptor family to fully understand its broad biological impact.

Pathways

Cytokine signaling pathways prominently involve CRLF3. Particularly it is part of the JAK-STAT signaling pathway which is important for mediating responses to various cytokines and growth factors. CRLF3 interacts with other signaling proteins including JAK kinases and STAT transcription factors to relay signals from external stimuli to the cell's interior influencing gene expression and affecting cellular responses.

Scientists have recognized connections between CRLF3 and neurological disorders. Research indicates that altered CRLF3 function may contribute to diseases such as multiple sclerosis and epilepsy. Furthermore its interaction with proteins relevant to immune response and neural signaling suggests potential roles in these conditions. Understanding CRLF3's involvement in these disorders could offer valuable insights into possible therapeutic strategies.
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Specifications

Form

Liquid

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General info

Function

May play a role in the negative regulation of cell cycle progression.

Sequence similarities

Belongs to the cytokine receptor-like factor 3 family.

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Product protocols

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Target data

May play a role in the negative regulation of cell cycle progression.
See full target information CRLF3
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Product promise

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