Recombinant Human CSN7A protein (denatured) is a Human Full Length protein, in the 1 to 275 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S A E V K V T G Q N Q E Q F L L L A K S A K G A A L A T L I H Q V L E A P G V Y V F G E L L D M P N V R E L A E S D F A S T F R L L T V F A Y G T Y A D Y L A E A R N L P P L T E A Q K N K L R H L S V V T L A A K V K C I P Y A V L L E A L A L R N V R Q L E D L V I E A V Y A D V L R G S L D Q R N Q R L E V D Y S I G R D I Q R Q D L S A I A R T L Q E W C V G C E V V L S G I E E Q V S R A N Q H K E Q Q L G L K Q Q I E S E V A N L K K T I K V T T A A A A A A T S Q D P E Q H L T E L R E P A P G T N Q R Q P S K K A S K G K G L R G S A K I W S K S N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Alternative names
CSN7A, DERP10, COPS7A, COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a
Recommended products
Recombinant Human CSN7A protein (denatured) is a Human Full Length protein, in the 1 to 275 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9UBW8-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M S A E V K V T G Q N Q E Q F L L L A K S A K G A A L A T L I H Q V L E A P G V Y V F G E L L D M P N V R E L A E S D F A S T F R L L T V F A Y G T Y A D Y L A E A R N L P P L T E A Q K N K L R H L S V V T L A A K V K C I P Y A V L L E A L A L R N V R Q L E D L V I E A V Y A D V L R G S L D Q R N Q R L E V D Y S I G R D I Q R Q D L S A I A R T L Q E W C V G C E V V L S G I E E Q V S R A N Q H K E Q Q L G L K Q Q I E S E V A N L K K T I K V T T A A A A A A T S Q D P E Q H L T E L R E P A P G T N Q R Q P S K K A S K G K G L R G S A K I W S K S N
- Accession
- Q9UBW8
- Protein length
- Full Length
- Predicted molecular weight
- 32.7 kDa
- Amino acids
- 1 to 275
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
- Sequence similarities
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
- Post-translational modifications
Phosphorylated by CK2 and PKD kinases.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as COPS7A
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1 product image
SDS-PAGE - Recombinant Human CSN7A protein (denatured) (ab180281)
15% SDS-PAGE analysis of ab180281 (3μg).
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