Recombinant Human CTBP2 protein is a Human Full Length protein, in the 1 to 445 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M A L V D K H K V K R Q R L D R I C E G I R P Q I M N G P L H P R P L V A L L D G R D C T V E M P I L K D L A T V A F C D A Q S T Q E I H E K V L N E A V G A M M Y H T I T L T R E D L E K F K A L R V I V R I G S G Y D N V D I K A A G E L G I A V C N I P S A A V E E T A D S T I C H I L N L Y R R N T W L Y Q A L R E G T R V Q S V E Q I R E V A S G A A R I R G E T L G L I G F G R T G Q A V A V R A K A F G F S V I F Y D P Y L Q D G I E R S L G V Q R V Y T L Q D L L Y Q S D C V S L H C N L N E H N H H L I N D F T I K Q M R Q G A F L V N A A R G G L V D E K A L A Q A L K E G R I R G A A L D V H E S E P F S F A Q G P L K D A P N L I C T P H T A W Y S E Q A S L E M R E A A A T E I R R A I T G R I P E S L R N C V N K E F F V T S A P W S V I D Q Q A I H P E L N G A T Y R Y P P G I V G V A P G G L P A A M E G I I P G G I P V T H N L P T V A H P S Q A P S P N Q P T K H G D N R E H P N E Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Recombinant protein. |
Target data
Function
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses.
Alternative names
C-terminal-binding protein 2, CtBP2, CTBP2
Recommended products
Recombinant Human CTBP2 protein is a Human Full Length protein, in the 1 to 445 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P56545-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M A L V D K H K V K R Q R L D R I C E G I R P Q I M N G P L H P R P L V A L L D G R D C T V E M P I L K D L A T V A F C D A Q S T Q E I H E K V L N E A V G A M M Y H T I T L T R E D L E K F K A L R V I V R I G S G Y D N V D I K A A G E L G I A V C N I P S A A V E E T A D S T I C H I L N L Y R R N T W L Y Q A L R E G T R V Q S V E Q I R E V A S G A A R I R G E T L G L I G F G R T G Q A V A V R A K A F G F S V I F Y D P Y L Q D G I E R S L G V Q R V Y T L Q D L L Y Q S D C V S L H C N L N E H N H H L I N D F T I K Q M R Q G A F L V N A A R G G L V D E K A L A Q A L K E G R I R G A A L D V H E S E P F S F A Q G P L K D A P N L I C T P H T A W Y S E Q A S L E M R E A A A T E I R R A I T G R I P E S L R N C V N K E F F V T S A P W S V I D Q Q A I H P E L N G A T Y R Y P P G I V G V A P G G L P A A M E G I I P G G I P V T H N L P T V A H P S Q A P S P N Q P T K H G D N R E H P N E Q
- Accession
- P56545
- Protein length
- Full Length
- Predicted molecular weight
- 75.06 kDa
- Amino acids
- 1 to 445
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).
- Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CTBP2 also known as C-terminal binding protein 2 is a transcriptional co-repressor involved in regulating gene expression. It is a protein with a molecular mass of approximately 48 kDa. CTBP2 is expressed in various tissues with high levels in neural muscular and epithelial cells. Mechanically CTBP2 operates by interacting with transcription factors and histone-modifying enzymes modulating chromatin structure to control access to DNA.
- Biological function summary
CTBP2 plays a significant role in cellular processes such as development and differentiation. It frequently acts as part of multi-protein complexes interacting with diverse partners to facilitate transcriptional repression. These interactions are essential for balancing gene activity ensuring appropriate tissue development and function. CTBP2 influences cellular dynamics by regulating target genes implicated in growth survival and metabolic pathways.
- Pathways
CTBP2 integrates into significant signaling pathways like Wnt and TGF-beta where it reinforces regulatory control by interacting with critical factors such as beta-catenin or Smad proteins. It collaborates with other proteins like CTBP1 dictating cellular responses and influencing pathophysiological processes. By coordinating these pathways CTBP2 supports cellular homeostasis impacting tissues in response to external and internal cues.
- Associated diseases and disorders
CTBP2 has associations with cancer and neurodegenerative diseases. Its overexpression or altered activity links to cancer progression as it promotes a transcriptional environment conducive to tumor growth. Proteins such as E-cadherin connect with CTBP2 in metastasis exemplifying its role in cancer cell dissemination. Additionally changes in CTBP2 function relate to neurodegenerative conditions affecting nerve cell survival and synaptic activity pointing to its involvement in neuronal health and disease mechanisms.
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1 product image
SDS-PAGE - Recombinant Human CTBP2 protein (ab114954)
12.5% SDS-PAGE showing ab114954 at approximately 75.06kDa.
Stained with Coomassie Blue.
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Product protocols
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