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AB275913

Recombinant Human CTDSP1 protein (GST tag N-Terminus)

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Recombinant Human CTDSP1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 260 aa range, expressed in Wheat germ, suitable for SDS-PAGE.

View Alternative Names

NIF3, NLIIF, SCP1, CTDSP1, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, Small C-terminal domain phosphatase 1, NLI-IF, NLI-interacting factor 3, Small CTD phosphatase 1

1 Images
SDS-PAGE - Recombinant Human CTDSP1 protein (GST tag N-Terminus) (AB275913)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CTDSP1 protein (GST tag N-Terminus) (AB275913)

12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9GZU7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB134594

Recombinant Human RNA polymerase II RPB11 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human RNA polymerase II RPB11 protein (His tag N-Terminus) (AB134594)

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Primary Antibodies

AB136038

Anti-CTDSP1 antibody

Western blot - Anti-CTDSP1 antibody (AB136038)

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  • 0
Proteins & Peptides

AB95318

Recombinant Human HSPC150/UBE2T protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human HSPC150/UBE2T protein (His tag C-Terminus) (AB95318)

  • 0
  • 0
Primary Antibodies

AB134114

Anti-CD19 antibody [EPR5906]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD19 antibody [EPR5906] (AB134114)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDSSAVITQISKEEARGPLRGKGDQKSAASKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKTPVQYLLPEAKAQDSDKIVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS","proteinLength":"Full Length","predictedMolecularWeight":"55.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":260,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9GZU7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTDSP1 also known as CTD small phosphatase 1 functions as an enzyme that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. This process regulates transcription elongation and termination. CTDSP1 has a molecular mass of approximately 30 kDa. The protein expresses widely with high levels found in the brain and ovary. It primarily operates within the nucleus reflecting its role in transcription regulation.
Biological function summary

CTDSP1 is involved in gene expression regulation by influencing RNA polymerase II activity. It belongs to a phosphatase family with related proteins like CTDSP2 and CTDSPL sharing overlapping functions. As a part of the CTD phosphatase complex CTDSP1 coordinates with other molecular players to manage gene expression outputs. This regulatory mechanism helps modulate responses to external and internal cellular signals.

Pathways

CTDSP1 takes part in the larger RNA transcription and processing pathways particularly the regulation of RNA polymerase II transcription. CTDSP1 interacts with factors like pre-mRNA splicing components affecting gene expression outcomes. It is associated with pathways that involve Cyclin-dependent kinase 9 (CDK9) which also influences RNA polymerase II activity through phosphorylation events demonstrating its key physiological interactions.

CTDSP1 has associations with neurological conditions and cancer. Its involvement in modulating gene expression links it to neurodegenerative disorders like Alzheimer's disease where transcription regulation plays a significant role in disease progression. Additionally changes in CTDSP1 activity relate to tumorigenesis with alterations in CTDSP1 or interacting proteins like CTDSP2 observed in various cancers. This makes CTDSP1 an interesting target for further research into diagnostic and therapeutic applications.
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Specifications

Form

Liquid

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General info

Function

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
See full target information CTDSP1
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