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AB174459

Recombinant Human CUEDC1 protein (His tag N-Terminus)

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Recombinant Human CUEDC1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 386 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CUE domain-containing protein 1, CUEDC1

1 Images
SDS-PAGE - Recombinant Human CUEDC1 protein (His tag N-Terminus) (AB174459)
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Supplier Data

SDS-PAGE - Recombinant Human CUEDC1 protein (His tag N-Terminus) (AB174459)

15% SDS-PAGE analysis of ab174459 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NWM3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPNMDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDSSDSEDSIPPEILERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGDANPAVSEDALFRDKLKHMGKSTRRKLFELARAFSEKTKMRKSKRKHLLKHQSLGAAASTANLLDDVEGHACDEDFRGRRQEAPKVEEGLREGQ","proteinLength":"Full Length","predictedMolecularWeight":"44.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":386,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NWM3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CUEDC1 also known as CUE domain-containing protein 1 is a protein with a mass of approximately 42 kDa. Mechanically CUEDC1 contains a CUE domain which is known to interact with ubiquitin. This domain enables CUEDC1 to play a significant role in protein-protein interactions. CUEDC1 is expressed in various human tissues including the brain liver and heart. Its expression pattern suggests its involvement in a broad range of physiological processes.
Biological function summary

The function of CUE domain-containing protein 1 revolves around its potential role in cellular signaling and regulation. It forms part of a complex that regulates protein degradation processes through the ubiquitin-proteasome system. This involvement suggests that CUEDC1 affects the stability of specific proteins within the cell influencing various cellular outcomes such as cell cycle and apoptosis.

Pathways

CUEDC1 functions within the ubiquitin-mediated proteolysis pathway influencing protein turnover and cellular homeostasis. It associates with proteins like ubiquitin ligases that modify proteins with ubiquitin tagging them for degradation. Additionally CUEDC1 interacts with components of the ERK/MAPK signaling pathway impacting cell proliferation and differentiation.

CUEDC1 links to cancer and neurodegenerative diseases. Altered expression levels of CUEDC1 have been observed in certain cancers suggesting it may influence tumor progression. Additionally disruptions in its function might contribute to neurodegenerative conditions possibly through its role in the degradation of misfolded proteins connecting to proteins like tau known to aggregate in Alzheimer's disease.
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Specifications

Form

Liquid

Additional notes

ab174459 is purified by using conventional chromatography techniques.

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General info

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Product protocols

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Target data

See full target information CUEDC1
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