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AB111633

Recombinant Human CUTC protein

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Recombinant Human CUTC protein is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CGI-32, CUTC, Copper homeostasis protein cutC homolog

1 Images
SDS-PAGE - Recombinant Human CUTC protein (AB111633)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human CUTC protein (AB111633)

15% SDS-PAGE showing ab111633 at approximately 31.5kDa (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NTM9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMKRQGASSERKRARIPSGKAGAANGFLMEVCVDSVESAVNAERGGADRIELCSGLSEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREIEVMKADIRLAKLYGADGLVFGALTEDGHIDKELCMSLMAICRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIKRLIEQAKGRIVVMPGGGITDRNLQRILEGSGATEFHCSARSTRDSGMKFRNSSVAMGASLSCSEYSLKVTDVTKVRTLNAIAKNILV","proteinLength":"Full Length","predictedMolecularWeight":"31.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":273,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NTM9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CUTC also known as copper homeostasis protein CUTC plays a role in copper transport and homeostasis. It has a molecular mass of approximately 30 kDa. CUTC expression occurs mainly in the liver kidney and intestines suggesting its importance in managing systemic copper levels. CUTC contains several copper-binding motifs that help it in coordinating and potentially transporting copper ions across cellular compartments.
Biological function summary

Copper homeostasis protein CUTC functions in the regulation of intracellular copper levels and may interact with copper chaperones. The protein does not work in isolation but instead might form complexes with other copper-binding proteins to facilitate efficient copper regulation. Proper function of CUTC is necessary for various copper-dependent enzymatic activities highlighting its role in maintaining cellular copper sufficiency.

Pathways

CUTC is engaged in the copper homeostasis pathway that ensures adequate copper distribution and detoxification. This protein is associated with other copper-related proteins like ATP7A/B which transport copper across cellular membranes. Through these interactions CUTC assists in protecting cells from copper toxicity and supports essential biological functions requiring copper.

CUTC relates to Wilson's disease and Menkes disease which are disorders of copper metabolism. CUTC interacts with proteins such as ATP7B in Wilson's disease and ATP7A in Menkes disease. Understanding CUTC's function and interactions is key for developing therapeutic strategies aimed at alleviating symptoms associated with impaired copper homeostasis in these conditions.
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Specifications

Form

Liquid

Additional notes

ab111633 was purified using conventional chromatography techniques.

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General info

Function

May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

Sequence similarities

Belongs to the CutC family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
See full target information CUTC
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Complementary Products

Primary Antibodies

AB133762

Anti-CUTC antibody [EPR7929]

RabMAb|Recombinant|KO Validated

Western blot - Anti-CUTC antibody [EPR7929] (AB133762)

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Cell Lines & Lysates

AB258388

Human CUTC knockout HeLa cell lysate

Western blot - Human CUTC knockout HeLa cell lysate (AB258388)

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Cell Lines & Lysates

AB265860

Human CUTC knockout HeLa cell line

Advanced Validation

Western blot - Human CUTC knockout HeLa cell line (AB265860)

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