Recombinant Human CUTC protein is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M K R Q G A S S E R K R A R I P S G K A G A A N G F L M E V C V D S V E S A V N A E R G G A D R I E L C S G L S E G G T T P S M G V L Q V V K Q S V Q I P V F V M I R P R G G D F L Y S D R E I E V M K A D I R L A K L Y G A D G L V F G A L T E D G H I D K E L C M S L M A I C R P L P V T F H R A F D M V H D P M A A L E T L L T L G F E R V L T S G C D S S A L E G L P L I K R L I E Q A K G R I V V M P G G G I T D R N L Q R I L E G S G A T E F H C S A R S T R D S G M K F R N S S V A M G A S L S C S E Y S L K V T D V T K V R T L N A I A K N I L V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
Alternative names
CGI-32, CUTC, Copper homeostasis protein cutC homolog
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Recombinant Human CUTC protein is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9NTM9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M K R Q G A S S E R K R A R I P S G K A G A A N G F L M E V C V D S V E S A V N A E R G G A D R I E L C S G L S E G G T T P S M G V L Q V V K Q S V Q I P V F V M I R P R G G D F L Y S D R E I E V M K A D I R L A K L Y G A D G L V F G A L T E D G H I D K E L C M S L M A I C R P L P V T F H R A F D M V H D P M A A L E T L L T L G F E R V L T S G C D S S A L E G L P L I K R L I E Q A K G R I V V M P G G G I T D R N L Q R I L E G S G A T E F H C S A R S T R D S G M K F R N S S V A M G A S L S C S E Y S L K V T D V T K V R T L N A I A K N I L V
- Accession
- Q9NTM9
- Protein length
- Full Length
- Predicted molecular weight
- 31.5 kDa
- Amino acids
- 1 to 273
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab111633 was purified using conventional chromatography techniques.
General info
- Function
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
- Sequence similarities
Belongs to the CutC family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CUTC also known as copper homeostasis protein CUTC plays a role in copper transport and homeostasis. It has a molecular mass of approximately 30 kDa. CUTC expression occurs mainly in the liver kidney and intestines suggesting its importance in managing systemic copper levels. CUTC contains several copper-binding motifs that help it in coordinating and potentially transporting copper ions across cellular compartments.
- Biological function summary
Copper homeostasis protein CUTC functions in the regulation of intracellular copper levels and may interact with copper chaperones. The protein does not work in isolation but instead might form complexes with other copper-binding proteins to facilitate efficient copper regulation. Proper function of CUTC is necessary for various copper-dependent enzymatic activities highlighting its role in maintaining cellular copper sufficiency.
- Pathways
CUTC is engaged in the copper homeostasis pathway that ensures adequate copper distribution and detoxification. This protein is associated with other copper-related proteins like ATP7A/B which transport copper across cellular membranes. Through these interactions CUTC assists in protecting cells from copper toxicity and supports essential biological functions requiring copper.
- Associated diseases and disorders
CUTC relates to Wilson's disease and Menkes disease which are disorders of copper metabolism. CUTC interacts with proteins such as ATP7B in Wilson's disease and ATP7A in Menkes disease. Understanding CUTC's function and interactions is key for developing therapeutic strategies aimed at alleviating symptoms associated with impaired copper homeostasis in these conditions.
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1 product image
SDS-PAGE - Recombinant Human CUTC protein (ab111633)
15% SDS-PAGE showing ab111633 at approximately 31.5kDa (3μg).
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